Our research is centered on investigating cysteine-based redox signaling in physiology and diseases. Many biological processes are regulated by redox chemistry mediated by oxidases, redox enzymes, and metabolic states, which are often dysregulated in diseases, including cancer and heart diseases. We are interested in interrogating redox-mediated biological processes, especially using a suite of chemical tools and methods that enable an understanding of protein cysteine oxidation at the molecular level. We use various interdisciplinary approaches, including synthetic chemistry, protein biochemistry, molecular biology, cell biology, and mouse studies, to understand the protein chemistry behind redox biology.