Book chapter
Intrathecal Delivery of Stem Cells to the Spinal Cord
Drug Delivery to the Central Nervous System
01 Jan 2010
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Cellular transplantation is a promising therapeutic strategy for spinal cord injury (SCI); the clinical application of transplantation, however, will require safe and efficient protocols of cell delivery. Lumbar puncture (LP) is a minimally invasive delivery method that allows multiple cell deliveries into the intrathecal space, resulting in cell accumulation at the site of injury. Here we review the effectiveness of the LP technique in rodent models of SCI, the advantages of LP compared to traditional parenchymal injection and other minimally invasive methods, and provide detailed instructions for LP delivery of stem cells to the injured rat spinal cord.
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Details
- Title
- Intrathecal Delivery of Stem Cells to the Spinal Cord
- Creators
- Birgit Neuhuber - Drexel UniversityItzhak Fischer - Drexel University
- Contributors
- K K Jain (Editor)
- Publication Details
- Drug Delivery to the Central Nervous System
- Series
- Neuromethods
- Publisher
- Humana Press Inc; TOTOWA
- Number of pages
- 14
- Resource Type
- Book chapter
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000274229700010
- Scopus ID
- 2-s2.0-73849103514
- Other Identifier
- 991019169665904721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Cell Biology
- Neurosciences