Review
Regulation of cGMP synthesis in photoreceptors: role in signal transduction and congenital diseases of the retina
Cellular Signalling, v 12(11), pp 711-719
01 Dec 2000
PMID: 11152956
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Calcium feedback in vertebrate photoreceptors regulates synthesis of cGMP, a second messenger in phototransduction. The decrease in the free intracellular Ca
2+ concentrations caused by illumination stimulates two isoforms of retinal membrane guanylyl cyclase (RetGC) via Ca
2+-sensor proteins and thus contributes to photoreceptor recovery and light adaptation. Unlike other members of the membrane guanylyl cyclase family, retinal guanylyl cyclases do not have identified extracellular peptide ligands. Recoverin-like proteins, GCAP-1 and GCAP-2, interact with the intracellular portion of the cyclases and stimulate its activity through dimerization of the cyclase subunits. Several mutations that affect the function of photoreceptor guanylyl cyclase and the activator protein have been linked to various forms of congenital human retinal diseases, such as Leber congenital amaurosis, cone and cone–rod dystrophy.
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Details
- Title
- Regulation of cGMP synthesis in photoreceptors: role in signal transduction and congenital diseases of the retina
- Creators
- Alexander M Dizhoor - Kresge Eye Institute
- Publication Details
- Cellular Signalling, v 12(11), pp 711-719
- Publisher
- Elsevier Inc
- Number of pages
- 9
- Resource Type
- Review
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000166048900002
- Scopus ID
- 2-s2.0-0034528347
- Other Identifier
- 991022035114304721
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- Web of Science research areas
- Cell Biology