Conference proceeding
Multi-rate nonlinear state and parameter estimation in a bioreactor
Proceedings of the 1998 American Control Conference. ACC (IEEE Cat. No.98CH36207), v 4, pp 2324-2328 vol.4
1998
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
This paper concerns real-time, multirate, nonlinear, state and parameter estimation in a pilot-scale, mouse-mouse hybridoma cell, biochemical reactor. A multirate estimator was designed and implemented to estimate specific growth rate and concentrations of viable cells, total cells, glucose, glutamine, and monoclonal antibodies (MAb) in the reactor. These were estimated from frequent measurement (inferred values) of oxygen uptake rate (OUR) and infrequent and delayed measurements of the concentrations of viable cells, total cells, glucose, glutamine, and MAb. The infrequent measurements were available every 2 to 17 hours with time delays of 0.08 to 2.00 hours, and OUR was inferred from dissolved oxygen concentration measurements that were available every 0.17 hour.
Metrics
Details
- Title
- Multi-rate nonlinear state and parameter estimation in a bioreactor
- Creators
- S Tatiraju - Drexel UniversityM Soroush - Drexel UniversityR Mutharasan - Drexel UniversityAMER AUTOMAT CONTROL COUNCIL
- Publication Details
- Proceedings of the 1998 American Control Conference. ACC (IEEE Cat. No.98CH36207), v 4, pp 2324-2328 vol.4
- Publisher
- IEEE
- Resource Type
- Conference proceeding
- Language
- English
- Academic Unit
- Chemical and Biological Engineering
- Web of Science ID
- WOS:000075568200496
- Scopus ID
- 2-s2.0-84881320365
- Other Identifier
- 991019173443004721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Automation & Control Systems
- Computer Science, Interdisciplinary Applications