Editorial
Of Mice and Men (and Effects of Gene Silencing)
Circulation (New York, N.Y.), v 120(12), pp 1027-1028
22 Sep 2009
PMID: 19738133
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
In this issue of Circulation, Zheng and coworkers1 demonstrate the efficacy of specific small interfering RNAs (siRNAs) added to University of Wisconsin solution in protecting donor hearts against cold ischemic injury during storage and subsequent reperfusion. siRNAs targeted tumor necrosis factor-α, C3, and Fas. The study design was well rationalized and performed systematically to confirm the efficacy of these siRNA constructs in silencing their respective targets, first in cell culture and subsequently in whole mouse hearts. Quantitative polymerase chain reaction was used to demonstrate knockdown of each of these proteins after ischemia and reperfusion in contrast to their strong upregulation in control hearts. Beneficial effects were confirmed by enhanced function, decreased apoptosis, diminished neutrophil activation and infiltration, and less histological evidence of tissue damage in the treated hearts.
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Details
- Title
- Of Mice and Men (and Effects of Gene Silencing)
- Creators
- Andrew S. Wechsler - Drexel University, College of MedicineJ. Yasha Kresh - Drexel University, College of Medicine
- Publication Details
- Circulation (New York, N.Y.), v 120(12), pp 1027-1028
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 2
- Resource Type
- Editorial
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:000270015600002
- Other Identifier
- 991014878544204721
UN Sustainable Development Goals (SDGs)
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Source: SDGs in the Output
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Cardiac & Cardiovascular Systems
- Peripheral Vascular Disease