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Accepted (AM)Open Access (License Unspecified), Open
Journal article
A Mixture of Urinary Phthalate Metabolite Concentrations During Pregnancy and Offspring Social Responsiveness Scale Scores
Epidemiology (Cambridge, Mass.), v 35(1), pp 84-93
Jan 2024
PMID: 37820223
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background:Phthalates are a group of chemicals with ubiquitous exposure worldwide. Exposures to phthalates during pregnancy may play a role in autism spectrum disorder (ASD) etiology by disrupting hormone levels or directly impacting fetal neurodevelopment. However, there is little research quantifying the aggregate effect of phthalates on child ASD-related behaviors.Methods:We used data from two prospective pregnancy and birth cohorts-the Health Outcomes and Measures of the Environment (HOME) and the Early Autism Risk Longitudinal Investigation (EARLI). HOME is a general population cohort while participants in EARLI were at higher familial risk for ASD. Using quantile g-computation and linear regression models, we assessed the joint and individual associations of a mixture of six phthalate metabolites during pregnancy with child ASD-related traits measured by Social Responsiveness Scale (SRS) scores at ages 3-8 years.Results:Our analyses included 271 participants from HOME and 166 participants from EARLI. There were imprecise associations between the phthalate mixture and SRS total raw scores in HOME (difference in SRS scores per decile increase in every phthalate = 1.3; 95% confidence interval [CI] = -0.2, 2.8) and EARLI (difference in SRS scores per decile increase in every phthalate = -0.9; 95% CI = -3.5, 1.7).Conclusions:The cohort-specific effect sizes of the pthalates-SRS associations were small and CIs were imprecise. These results suggest that if there are associations between phthalate metabolites during pregnancy and child SRS scores, they may differ across populations with different familial liabilities. Further studies with larger sample sizes are warranted.
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- Title
- A Mixture of Urinary Phthalate Metabolite Concentrations During Pregnancy and Offspring Social Responsiveness Scale Scores
- Creators
- Emma X. Yu - Johns Hopkins UniversityJoseph M. Braun - Brown UniversityKristen Lyall - Drexel University, Epidemiology and BiostatisticsIrva Hertz-Picciotto - Univ Calif Davis, Sch Med, Dept Publ Hlth Sci, Davis, CA USAM. Daniele Fallin - Emory UniversityLisa A. Croen - Kaiser PermanenteAimin Chen - University of PennsylvaniaYingying Xu - University of CincinnatiKimberly Yolton - University of CincinnatiCraig J. Newschaffer - Penn State Univ, Dept Biobehav Hlth, University Pk, PA USAGhassan B. Hamra - Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA
- Publication Details
- Epidemiology (Cambridge, Mass.), v 35(1), pp 84-93
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 10
- Grant note
- 003953 / Autism Speaks R01ES016443; R24ES030893 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA P01ES011261; R01ES014575; R01ES020349; R01 ES024381; R01 ES032836 / U.S. Environmental Protection Agency; United States Environmental Protection Agency
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:001111316300005
- Scopus ID
- 2-s2.0-85178498886
- Other Identifier
- 991021861302304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health