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Journal article
A prospective study of thymectomy and serum acetylcholine receptor antibodies in myasthenia gravis
Annals of surgery, v 196(2), pp 113-121
01 Aug 1982
PMID: 7092360
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Abstract
Forty-seven consecutively presenting myasthenia gravis (MG) patients with generalized weakness were treated according to a standardized prospective protocol. All patients underwent a sternal splitting "total" thymectomy. Medical status before surgery was optimized by plasmapheresis without immunosuppression. Medications were avoided or discontinued whenever possible. All patients were improved. At the time of latest follow-up 83% were free of generalized weakness and 61% were on no medications. There was no significant change in Acetylcholine Receptor Antibody (AChR-AB) titer. The following conclusions were made: (1) thymectomy is an effective therapy for MG, (2) additional medications are not necessary in the majority of patients, and (3) a reduction in the AChR-AB titer is not essential for clinical benefit.
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Details
- Title
- A prospective study of thymectomy and serum acetylcholine receptor antibodies in myasthenia gravis
- Creators
- C W OlanowA S Wechsler - Duke Medical CenterA D Roses - Duke Medical Center
- Publication Details
- Annals of surgery, v 196(2), pp 113-121
- Publisher
- Lippincott
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]
- Web of Science ID
- WOS:A1982NZ56900001
- Scopus ID
- 2-s2.0-0019940470
- Other Identifier
- 991020705324804721
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- Web of Science research areas
- Surgery