Journal article
A reproducible model of moderate to severe concentric left ventricular hypertrophy
The American journal of physiology, v 234(5), pp H515-H519
May 1978
PMID: 148215
Abstract
A reproducible model for the production of moderate to severe concentric left ventricular hypertrophy has been developed in this laboratory. Coarctation-banding of the ascending aorta was performed successfully in 10 puppies. There were no late deaths related to aortic rupture, and in the dogs surviving for 1 yr no evidence of congestive heart failure was present. A second operative procedure was performed in seven dogs for chronic instrumentation, and all survived. Severe supravalvular aortic stenosis with a marked peak systolic pressure gradient was noted in each dog. Postmortem examination revealed a substantial increase in left ventricular mass and in the ratio of left ventricular to body weight.
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Details
- Title
- A reproducible model of moderate to severe concentric left ventricular hypertrophy
- Creators
- L H KleinmanA S WechslerJ C RembertJ M FedorJ C Greenfield
- Publication Details
- The American journal of physiology, v 234(5), pp H515-H519
- Publisher
- American Physiological Society (APS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]
- Web of Science ID
- WOS:A1978EZ99300030
- Scopus ID
- 2-s2.0-0018232413
- Other Identifier
- 991020705346504721