Journal article
Accelerated epigenetic age at birth and child emotional and behavioura development in early childhood: a meta-analysis of four prospective cohort studies in ECHO
Epigenetics, v 18(1), 2254971
Dec 2023
PMID: 37691382
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
'Epigenetic clocks' have been developed to accurately predict chronologic gestational age and have been associated with child health outcomes in prior work.
We meta-analysed results from four prospective U.S cohorts investigating the association between epigenetic age acceleration estimated using blood DNA methylation collected at birth and preschool age Childhood Behavior Checklist (CBCL) scores.
Epigenetic ageing was not significantly associated with CBCL total problem scores (β = 0.33, 95% CI: -0.95, 0.28) and DSM-oriented pervasive development problem scores (β = -0.23, 95% CI: -0.61, 0.15). No associations were observed for other DSM-oriented subscales.
The meta-analysis results suggest that epigenetic gestational age acceleration is not associated with child emotional and behavioural functioning for preschool age group. These findings may relate to our study population, which includes two cohorts enriched for ASD and one preterm birth cohort.; future work should address the role of epigenetic age in child health in other study populations.
DNAm: DNA methylation; CBCL: Child Behavioral Checklist; ECHO: Environmental Influences on Child Health Outcomes; EARLI: Early Autism Risk Longitudinal Investigation; MARBLES: Markers of Autism Risk in Babies - Learning Early Signs; ELGAN: Extremely Low Gestational Age Newborns; ASD: autism spectrum disorder; BMI: body mass index; DSM: Diagnostic and Statistical Manual of Mental Disorders.
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Details
- Title
- Accelerated epigenetic age at birth and child emotional and behavioura development in early childhood: a meta-analysis of four prospective cohort studies in ECHO
- Creators
- Ashley Y Song - Johns Hopkins UniversityCatherine M Bulka - University of North Carolina at Chapel HillSierra S Niemiec - Colorado School of Public HealthKaterina Kechris - Colorado School of Public HealthKristen E Boyle - University of Colorado Anschutz Medical CampusCarmen J Marsit - Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USAT Michael O'Shea - Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC, USARebecca C Fry - Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USAKristen Lyall - Drexel University, Epidemiology and BiostatisticsM Daniele Fallin - Emory UniversityHeather E Volk - Johns Hopkins UniversityChristine Ladd-Acosta - Johns Hopkins University
- Publication Details
- Epigenetics, v 18(1), 2254971
- Publisher
- Taylor & Francis
- Grant note
- P30 ES010126 / NIEHS NIH HHS UG3 OD023348 / NIH HHS U24 OD023319 / NIH HHS UH3 OD023342 / NIH HHS U2C OD023375 / NIH HHS U24 OD023382 / NIH HHS UH3 OD023348 / NIH HHS UH3 OD023248 / NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics; Drexel University
- Web of Science ID
- WOS:001062984500001
- Scopus ID
- 2-s2.0-85170488723
- Other Identifier
- 991021860617504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Genetics & Heredity