Journal article
Accelerated epigenetic age at birth and child emotional and behavioura development in early childhood: a meta-analysis of four prospective cohort studies in ECHO
EPIGENETICS, v 18(1), 2254971
31 Dec 2023
PMID: 37691382
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background: 'Epigenetic clocks' have been developed to accurately predict chronologic gestational age and have been associated with child health outcomes in prior work.Methods: We meta-analysed results from four prospective U.S cohorts investigating the association between epigenetic age acceleration estimated using blood DNA methylation collected at birth and preschool age Childhood Behavior Checklist (CBCL) scores.Results: Epigenetic ageing was not significantly associated with CBCL total problem scores (& beta; = 0.33, 95% CI: -0.95, 0.28) and DSM-oriented pervasive development problem scores (& beta; = -0.23, 95% CI: -0.61, 0.15). No associations were observed for other DSM-oriented subscales.Conclusions: The meta-analysis results suggest that epigenetic gestational age acceleration is not associated with child emotional and behavioural functioning for preschool age group. These findings may relate to our study population, which includes two cohorts enriched for ASD and one preterm birth cohort.; future work should address the role of epigenetic age in child health in other study populations.Abbreviations: DNAm: DNA methylation; CBCL: Child Behavioral Checklist; ECHO: Environmental Influences on Child Health Outcomes; EARLI: Early Autism Risk Longitudinal Investigation; MARBLES: Markers of Autism Risk in Babies - Learning Early Signs; ELGAN: Extremely Low Gestational Age Newborns; ASD: autism spectrum disorder; BMI: body mass index; DSM: Diagnostic and Statistical Manual of Mental Disorders.
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Details
- Title
- Accelerated epigenetic age at birth and child emotional and behavioura development in early childhood: a meta-analysis of four prospective cohort studies in ECHO
- Publication Details
- EPIGENETICS, v 18(1), 2254971
- Publisher
- TAYLOR & FRANCIS INC; PHILADELPHIA
- Grant note
- The work was supported by the National Institutes of Health. The content is solely the responsibility of the authors and & nbsp;does not necessarily represent the official views of the National Institutes of Health.Research reported in this publication was supported by the Environmental influences on Child Health Outcomes (ECHO) program, Office of the Director, National Institutes of Health, under Award Numbers [U2COD023375] (Coordinating Center), [U24OD023382] (Data Analysis Center), [U24OD023319] with co-funding from the Office of Behavioral and Social Science Research (PRO Core), [UH3OD023248] (Dabelea), [UH3OD023342] (Lyall), [UH3OD023348] (O'Shea).
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Drexel University
- Web of Science ID
- WOS:001062984500001
- Scopus ID
- 2-s2.0-85170488723
- Other Identifier
- 991021860617504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Genetics & Heredity