Journal article
Activation Mechanism Design for a Dual-Blood Pumping System for Pediatric Heart Failure
Artificial organs, v 50(1), pp 74-83
Jan 2026
PMID: 40704826
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
ObjectivePediatric patients face significant challenges in the treatment of end-stage congenital or acquired heart failure (HF). Mechanical circulatory support (MCS) devices can serve as a bridge to transplant, but the few available MCS solutions are associated with deleterious patient outcomes when compared to adults. We are working to address this gap by developing a novel double-blood pump VAD to provide effective single-device support across the pediatric age range. Our innovative design integrates both an axial pump and a centrifugal pump in one implantable device and utilizes a unique mechanism to activate the secondary centrifugal pump as cardiac demands increase.MethodsWe developed a configuration for the novel activation mechanism through virtual studies against functional requirements and anatomical fit constraints, iteratively improved the activation mechanism design to meet qualitative and quantitative design targets, evaluated the design through in vitro functional and hydraulic experimentation, and determined the hemolytic profile of the proposed design through hemolytic flow loop testing and analysis.ResultsMultiple iterations of design improvements resulted in a prototype that could effectively and repeatably actuate in situ while providing leak-free support at physiological pressures and flows. Hemolytic testing demonstrated that the blood damage potential is low.ConclusionThe results from this study validate the proposed activation mechanism design and support the continued translational development of the Drexel Double Dragon VAD.
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Details
- Title
- Activation Mechanism Design for a Dual-Blood Pumping System for Pediatric Heart Failure
- Creators
- Thomas C. Palazzolo - Drexel Univ, Sch Biomed Engn Sci & Hlth Syst, BioCirc Res Lab, Philadelphia, PA 19104 USAGiselle C. Matlis - Drexel University, School of Biomedical Engineering, Science, and Health SystemsEthan Pastor - Drexel UniversityAshwini Selvakumar - Drexel UniversityAidan Crozier - Drexel UniversityVakhtang Tchantchaleishvili - Thomas Jefferson UniversityRandy M. Stevens - Drexel University, PediatricsAmy L. Throckmorton - Drexel University, School of Biomedical Engineering, Science, and Health Systems
- Publication Details
- Artificial organs, v 50(1), pp 74-83
- Publisher
- Wiley
- Number of pages
- 10
- Grant note
- National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics; School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:001534619400001
- Scopus ID
- 2-s2.0-105011828698
- Other Identifier
- 991022065410304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Engineering, Biomedical
- Transplantation