Journal article
Analysis of GP73 in patients with HCC as a function of anti-cancer treatment
Cancer biomarkers : section A of Disease markers, v 7(6), pp 269-273
01 Jan 2010
PMID: 21694465
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
In this study, we examined the level of Golgi protein 73 (GP73) in the serum of 9 patients as a function of anti-liver cancer treatment. Although the numbers are small, a clear trend was observed. Patients who remained tumor free (up to 6 years post-treatment) showed reductions in GP73 at the first time point available post-treatment. In contrast, patients who had high levels GP73 post treatment all had re-occurrence within a 5 year period. These data are preliminary but dramatically imply that this marker may have value in the monitoring of HCC patients and may be elevated even when small, undetectable tumors are present.
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Details
- Title
- Analysis of GP73 in patients with HCC as a function of anti-cancer treatment
- Creators
- Hie-Won Hann - Liver Disease Prevention Center, Division of Gastroenterology and Hepatology, Jefferson Medical College, Thomas Jefferson University Hospital, Philadelphia, PA, 19107Mengjun Wang - Drexel University College of Medicine, 3805 Old Easton Road, Doylestown, PA, 18902Julie Hafner - Immunotope Inc., 3805 Old Easton Road, Doylestown, PA, 18902Ronald E Long - Drexel University College of Medicine, 3805 Old Easton Road, Doylestown, PA, 18902Su Hee Kim - Liver Disease Prevention Center, Division of Gastroenterology and Hepatology, Jefferson Medical College, Thomas Jefferson University Hospital, Philadelphia, PA, 19107Meejin Ahn - Liver Disease Prevention Center, Division of Gastroenterology and Hepatology, Jefferson Medical College, Thomas Jefferson University Hospital, Philadelphia, PA, 19107Susan Park - Liver Disease Prevention Center, Division of Gastroenterology and Hepatology, Jefferson Medical College, Thomas Jefferson University Hospital, Philadelphia, PA, 19107Mary Ann Comunale - Drexel University College of Medicine, 3805 Old Easton Road, Doylestown, PA, 18902Timothy M Block - Drexel University College of Medicine, 3805 Old Easton Road, Doylestown, PA, 18902Anand Mehta - Drexel University College of Medicine, 3805 Old Easton Road, Doylestown, PA, 18902
- Publication Details
- Cancer biomarkers : section A of Disease markers, v 7(6), pp 269-273
- Publisher
- IOS Press
- Grant note
- U01 CA084951-06 || CA / National Cancer Institute : NCI
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000292852800002
- Scopus ID
- 2-s2.0-79959709520
- Other Identifier
- 991014877900104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Oncology