Journal article
Antimicrobial Mode-of-Action of Colloidal Ti3C2TX MXene Nanosheets
ACS sustainable chemistry & engineering, v 6(12), pp 16586-16596
01 Dec 2018
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Antibacterial properties of two-dimensional (2D) nanomaterials are of great interest in fields such as environmental engineering, biomedical engineering, and medicine. Ti3C2Tx MXene, a novel 2D nanomaterial, has been reported to have excellent antibacterial activity against both Gram-negative and Gram-positive bacteria. This paper presents the first study aimed at determining the primary antibacterial mode-of-action of the MXene. We studied the antibacterial properties of MXene nanosheets with lateral sizes of 0.09, 0.35, 0.57, and 4.40 mu m against Escherichia coli and Bacillus subtilis bacteria for 3 and 8 h in the dark. Quantitative analyses of bacteria species performed with complementary techniques, fluorescence imaging, and flow cytometry confirmed that the antibacterial activity of the MXene nanosheets is both size- and exposure-time-dependent. Smaller nanosheets showed higher antibacterial activities against both bacteria. For the first time, we applied broth microdilution assay to determine whether direct physical interactions between the MXene nanosheets and bacteria cells play a part in antibacterial properties of the nanosheets. Growth kinetics measurements evidently indicate that direct physical interactions between the sharp edges of the nanosheets and bacteria membrane surfaces play a crucial part in antibacterial properties of the nanosheets. The MXene nanosheets were found to damage the bacterial cells significantly in less than 3 h, leading to the release of bacteria DNA from the cytosol followed by bacteria cell dispersion. These results point to the great potential of MXene-based antibacterial products for water treatment, medical, and biomedical applications.
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Details
- Title
- Antimicrobial Mode-of-Action of Colloidal Ti3C2TX MXene Nanosheets
- Creators
- Ahmad Arabi Shamsabadi - Drexel UniversityMohammad Sharifian Gh - Temple Univ, Dept Chem, Philadelphia, PA 19122 USABabak Anasori - Department of Materials Science and Engineering and A.J. Drexel Nanomaterials Institute , Drexel University , Philadelphia , Pennsylvania 19104 , United States.Masoud Soroush - Drexel University
- Publication Details
- ACS sustainable chemistry & engineering, v 6(12), pp 16586-16596
- Publisher
- American Chemical Society; Washington, DC
- Number of pages
- 21
- Grant note
- CHE-1465096 / NSF; National Science Foundation (NSF) CBET-1804285 / U.S. National Science Foundation (NSF); National Science Foundation (NSF)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Chemical and Biological Engineering
- Web of Science ID
- WOS:000452344900071
- Scopus ID
- 2-s2.0-85057576229
- Other Identifier
- 991019168132904721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Chemistry, Multidisciplinary
- Engineering, Chemical
- Green & Sustainable Science & Technology