Journal article
Association Between Midpregnancy Polyunsaturated Fatty Acid Levels and Offspring Autism Spectrum Disorder in a California Population-Based Case-Control Study
American journal of epidemiology, v 190(2), pp 265-276
01 Feb 2021
PMID: 33524118
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Polyunsaturated fatty acids (PUFAs) are critical for brain development and have been linked with neurodevelopmental outcomes. We conducted a population-based case-control study in California to examine the association between PUFAs measured in midpregnancy serum samples and autism spectrum disorder (ASD) in offspring. ASD cases (n = 499) were identified through the California Department of Developmental Services and matched to live-birth population controls (n = 502) on birth month, year (2010 or 2011), and sex. Logistic regression models were used to examine crude and adjusted associations. In secondary analyses, we examined ASD with and without co-occurring intellectual disability (ID; n = 67 and n = 432, respectively) and effect modification by sex and ethnicity. No clear patterns emerged, though there was a modest inverse association with the top quartile of linoleic acid level (highest quartile vs. lowest: adjusted odds ratio = 0.74, 95% confidence interval: 0.49, 1.11; P for trend = 0.10). Lower levels of total and omega-3 PUFAs were associated with ASD with ID (lowest decile of total PUFAs vs. deciles 4-7: adjusted odds ratio = 2.78, 95% confidence interval: 1.13, 6.82) but not ASD without ID. We did not observe evidence of effect modification by the factors examined. These findings do not suggest a strong association between midpregnancy PUFA levels and ASD. In further work, researchers should consider associations with ASD with ID and in other time windows.
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Details
- Title
- Association Between Midpregnancy Polyunsaturated Fatty Acid Levels and Offspring Autism Spectrum Disorder in a California Population-Based Case-Control Study
- Creators
- Kristen Lyall - Drexel UniversityGayle C. Windham - California Department of Public HealthNathaniel W. Snyder - Drexel UniversityRostislav Kuskovsky - Drexel UniversityPeining Xu - Drexel UniversityAnna Bostwick - Drexel UniversityLucy Robinson - Drexel UniversityCraig J. Newschaffer - Drexel University
- Publication Details
- American journal of epidemiology, v 190(2), pp 265-276
- Publisher
- Oxford Univ Press
- Number of pages
- 12
- Grant note
- K22 ES026235; R03 CA211820 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA AR150143 / US Army Medical Research Acquisition Activity through Autism Spectrum Disorder Research Program IDEA Development Award
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics; A.J. Drexel Autism Institute
- Web of Science ID
- WOS:000636958300010
- Scopus ID
- 2-s2.0-85092053712
- Other Identifier
- 991019168115304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health