Files and links (1)
Published, Version of Record (VoR)CC BY V4.0, Open
Journal article
Association between self-reported caffeine intake during pregnancy and social responsiveness scores in childhood: The EARLI and HOME studies
PloS one, v 16(1), pp e0245079-e0245079
2021
PMID: 33449933
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Maternal nutrition during gestation has been investigated for its role in child neurodevelopment. However, little is known about the potential impact of gestational caffeine exposure on child autistic behaviors. Here, we assess the relation between maternal caffeine intake during pregnancy and children's behavioral traits related to Autism Spectrum Disorder (ASD). We harmonized data from two pregnancy cohorts, Early Autism Risk Longitudinal Investigation (EARLI) (n = 120), an enriched-risk cohort of mothers who previously had a child with ASD, from Pennsylvania, Maryland, and Northern California (2009-2012), and the Health Outcomes and Measures of the Environment (HOME) Study (n = 269), a general population cohort from Cincinnati, Ohio (2003-2006). Mothers self-reported caffeine intake twice during pregnancy. Caregivers reported child behavioral traits related to ASD using the Social Responsiveness Scale (SRS) when children were aged 3-8 years. Higher scores indicate more ASD-related behaviors. We estimated covariate-adjusted differences in continuous SRS T-scores per interquartile range increase in caffeine intake. Self-reported caffeine intake during pregnancy was positively associated with SRS T-scores among children in EARLI (β: 2.0; 95% CI -0.1, 4.0), but to a lesser extent in HOME (β: 0.6; 95% CI -0.5, 1.6). In HOME, pre-pregnancy body mass index (BMI) modified the association between caffeine intake and SRS T-scores, where more positive associations were observed among women with higher BMIs. Our findings suggest gestational caffeine intake may represent a marker of vulnerability to childhood ASD-related behaviors. Additional studies are warranted to extend these findings.
Metrics
Details
- Title
- Association between self-reported caffeine intake during pregnancy and social responsiveness scores in childhood: The EARLI and HOME studies
- Creators
- Marisa A Patti - Brown UniversityNan Li - Brown UniversityMelissa Eliot - Brown UniversityCraig Newschaffer - Drexel UniversityKimberly Yolton - Cincinnati Children's Hospital Medical CenterJane Khoury - Cincinnati Children's Hospital Medical CenterAimin Chen - University of Cincinnati Medical CenterBruce P Lanphear - Simon Fraser UniversityKristen Lyall - Drexel UniversityIrva Hertz-Picciotto - University of California, DavisMargaret Daniele Fallin - Johns Hopkins UniversityLisa A Croen - Kaiser PermanenteJoseph M Braun - Brown University
- Publication Details
- PloS one, v 16(1), pp e0245079-e0245079
- Publisher
- Public LIbrary of Science (PLOS)
- Grant note
- R01 ES014575 / NIEHS NIH HHS R01 ES020349 / NIEHS NIH HHS R01 ES026903 / NIEHS NIH HHS P01 ES011261 / NIEHS NIH HHS R01 ES024381 / NIEHS NIH HHS R01 ES016443 / NIEHS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- A.J. Drexel Autism Institute
- Web of Science ID
- WOS:000609991600054
- Scopus ID
- 2-s2.0-85099816628
- Other Identifier
- 991019168642204721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health