Journal article
Association of Environmental Tobacco Smoke Exposure in Childhood With Early Emphysema in Adulthood Among Nonsmokers
American journal of epidemiology, v 171(1), pp 54-62
01 Jan 2010
PMID: 19942575
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Mechanical stress to alveolar walls may cause progressive damage after an early-life insult such as exposure to environmental tobacco smoke (ETS). This hypothesis was examined by using data from the Multi-Ethnic Study of Atherosclerosis (MESA), a population-based cohort aged 45-84 years, free of clinical cardiovascular disease, recruited from 6 US sites in 2000-2002. The MESA-Lung Study assessed a fractal, structural measure of early emphysema ("alpha," lower values indicate more emphysema) and a standard quantitative measure ("percent emphysema") from cardiac computed tomography scans. Childhood ETS exposure was assessed retrospectively as a report of living with one or more regular indoor smokers. Analyses included 1,781 nonsmokers (< 100 cigarettes, 20 cigars, or 20 pipefulls in their lifetime and urinary cotinine levels < 100 ng/mL); mean age was 61 years (standard deviation, 10), and 65% were women. Childhood ETS exposure from 2 or more smokers (17%) compared with none (52%) was associated with 0.05 lower alpha and 2.8 higher percent emphysema (P for trend = 0.04 and 0.01, respectively) after adjustment for demographic, anthropometric, parental, and participant characteristics, as well as adult exposures (e.g., cumulative residential air pollution exposure, exposure to ETS as an adult). Childhood ETS exposure was associated with detectable differences on computed tomography scans of adult lungs of nonsmokers.
Metrics
Details
- Title
- Association of Environmental Tobacco Smoke Exposure in Childhood With Early Emphysema in Adulthood Among Nonsmokers
- Creators
- Gina S. Lovasi - Columbia UniversityAna V. Diez Roux - University of MichiganEric A. Hoffman - University of IowaSteven M. Kawut - University of PennsylvaniaDavid R. Jacobs - University of MinnesotaR. Graham Barr - Columbia University
- Publication Details
- American journal of epidemiology, v 171(1), pp 54-62
- Publisher
- Oxford University Press
- Number of pages
- 9
- Grant note
- N01HC095159 / DIVISION OF EPIDEMIOLOGY AND CLINICAL APPLICATIONS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Eye Institute (NEI) R01-HL077612; R01-HL075476; N01-HC095159; HC095169 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R01HL075476 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) Robert Wood Johnson Foundation Health Society; Robert Wood Johnson Foundation (RWJF)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative; Dana and David Dornsife School of Public Health; Epidemiology and Biostatistics
- Web of Science ID
- WOS:000273112500007
- Scopus ID
- 2-s2.0-72949110934
- Other Identifier
- 991020099919904721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health