Journal article
Association of neurodevelopmental conditions with Alzheimer's disease and related dementias and Parkinson's disease
The journals of gerontology. Series A, Biological sciences and medical sciences, v 81(4), 281
10 Mar 2026
PMID: 41429566
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Neurodevelopmental conditions (NDC), including attention deficit/hyperactivity disorder (ADHD) and autism, are associated with increased rates of neurodegenerative diseases, including Alzheimer's disease and related dementias (ADRD) and Parkinson's disease. Such associations are unstudied in diverse populations and while controlling for a range of important covariates. The purpose of this study was to examine the association of ADRD and Parkinson's disease with NDCs in a diverse sample of adults.
This case-control study used data from the United States All of Us Research Program 2018-2023 from approximately 600 000 adults in the United States. We matched on ADRD and Parkinson's disease status to examine the association of these conditions with NDCs.
NDC was more prevalent in ADRD cases than in non-ADRD controls (7.8% vs 2.4%) and among Parkinson's disease cases than non-Parkinson's disease controls (4.5% vs 1.8%). After adjustment for sex, age, education level, body mass index, cardiometabolic conditions, and psychiatric conditions, individuals with ADRD had significantly higher odds of having an NDC compared with controls (adjusted odds ratio, 2.68; 95% CI, 2.40-2.99). Similarly, Parkinson's disease cases had 2.09 times the odds of having an NDC as non-Parkinson's disease controls (95% CI 1.66, 2.59) in adjusted models.
As the population of individuals with NDCs ages, and more older adults find themselves in the care of clinicians with expertise in ADRD and Parkinson's disease, it is imperative to understand the support needs of this population, and to provide targets for reducing ADRD prevalence in younger or middle adulthood.
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Details
- Title
- Association of neurodevelopmental conditions with Alzheimer's disease and related dementias and Parkinson's disease
- Creators
- Jessica E Rast - Drexel University, A.J. Drexel Autism InstituteAndrea L Rosso - Drexel UniversityBryan D James - Rush UniversityJack F G Underwood - University of Wales Institute CardiffJacob Bergstedt - Karolinska InstitutetViktor H Ahlqvist - Karolinska InstitutetJakob Grove - Aarhus UniversityFang Fang - Karolinska InstitutetNeal D Goldstein - Drexel University, Epidemiology and BiostatisticsGiacomo Vivanti - Drexel University, Psychological and Brain Sciences (Psychology)Stephen Z Levine - University of HaifaAnna Nordström - Uppsala UniversityDiana Schendel - Drexel University, A.J. Drexel Autism InstituteKristen Lyall - Drexel University, Epidemiology and BiostatisticsPeter Nordström - Uppsala UniversityMarcel Ballin - Uppsala UniversityJean Stafford - University of EdinburghAdam C Naj - University of PennsylvaniaBrian K Lee - Drexel University, Epidemiology and BiostatisticsLEGENNDS Consortium
- Publication Details
- The journals of gerontology. Series A, Biological sciences and medical sciences, v 81(4), 281
- Publisher
- Oxford University Press
- Grant note
- R01NS131433 / NIH HHS Alzheimer's Society Fellowship R01 NS131433 / NINDS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychological and Brain Sciences (Psychology); Epidemiology and Biostatistics; A.J. Drexel Autism Institute
- Web of Science ID
- WOS:001719368800001
- Scopus ID
- 2-s2.0-105034074643
- Other Identifier
- 991022146938204721
UN Sustainable Development Goals (SDGs)
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Source: SDGs in the Output
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Geriatrics & Gerontology
- Gerontology