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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Association of secondhand tobacco smoke exposure during childhood on adult cardiovascular disease risk among never-smokers
Annals of epidemiology, v 32, pp 28-34
Apr 2019
PMID: 30799203
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Adult secondhand tobacco smoke (SHS) exposure is related to stroke and coronary heart disease (CHD) risk, but long-term effects are less clear. We evaluated whether childhood SHS exposure affects subsequent stroke or CHD risk among adult black and white never-smokers followed for stroke and CHD.
In this prospective cohort study, inverse probability weights were calculated to correct for bias due to attrition and survey nonresponse. Cox proportional hazards models were used to assess hazard ratios and 95% confidence intervals for stroke or CHD, separately, by number of childhood household smokers.
Of 13,142 eligible participants, 6136 had childhood SHS exposure assessed. Baseline mean (SD) age was 63.5 (9.0), 65% were female, 30% black, 46% reported 0 childhood household smokers, 36% reported 1, and 18% reported 2+. In 60,649 person-years, 174 strokes were observed (2.9% of participants), and in 45,195 person-years, 114 CHD events were observed (2.1% of participants). The weighted and adjusted hazard ratios (95% confidence intervals) of stroke for 2+ versus 0 childhood household smokers was 1.66 (1.29–2.13) and was 1.15 (0.82–1.59) for CHD.
We observed a significant association between childhood SHS exposure and stroke, but not CHD, after age 45 years and adjusting for missing information.
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Details
- Title
- Association of secondhand tobacco smoke exposure during childhood on adult cardiovascular disease risk among never-smokers
- Creators
- Maxwell Pistilli - Drexel UniversityVirginia J. Howard - University of Alabama at BirminghamMonika M. Safford - Cornell UniversityBrian K. Lee - Drexel UniversityGina S. Lovasi - Drexel UniversityMary Cushman - University of VermontAngela M. Malek - Medical University of South CarolinaLeslie A. McClure - Drexel UniversityREGARDS Investigators
- Publication Details
- Annals of epidemiology, v 32, pp 28-34
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative; Epidemiology and Biostatistics
- Web of Science ID
- WOS:000464300600005
- Scopus ID
- 2-s2.0-85061788671
- Other Identifier
- 991019168116904721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health