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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Associations between neighborhood greenspace and brain imaging measures in non-demented older adults: the Cardiovascular Health Study
Social Psychiatry and Psychiatric Epidemiology, v 56(9), pp 1575-1585
2021
PMID: 33388800
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Purpose
Greater neighborhood greenspace has been associated with brain health, including better cognition and lower odds of Alzheimer’s disease in older adults. We investigated associations between neighborhood greenspace and brain-based magnetic resonance imaging (MRI) measures and potential effect modification by sex or apolipoprotein E genotype (APOE), a risk factor for Alzheimer’s disease.
Methods
We obtained a sample of non-demented participants 65 years or older (
n
= 1125) from the longitudinal, population-based Cardiovascular Health Study (CHS). Greenspace data were derived from the National Land Cover Dataset. Adjusted multivariable linear regression estimated associations between neighborhood greenspace five years prior to the MRI and left and right hippocampal volume and 10-point grades of ventricular size and burden of white matter hyperintensity. Interaction terms tested effect modification by APOE genotype and sex. CHS data (1989–1999) were obtained/analyzed in 2020.
Results
Participants were on average 79 years old [standard deviation (SD) = 4], 58% were female, and 11% were non-white race. Mean neighborhood greenspace was 38% (SD = 28%). Greater proportion of greenspace in the neighborhood five years before MRI was borderline associated with lower ventricle grade (estimate: − 0.30; 95% confidence interval: − 0.61, 0.00). We observed no associations between greenspace and the other MRI outcome measures and no evidence of effect modification by APOE genotype and sex.
Conclusion
This study suggests a possible association between greater greenspace and less ventricular enlargement, a measure reflecting global brain atrophy. If confirmed in other longitudinal cohort studies, interventions and policies to improve community greenspaces may help to maintain brain health in older age.
Metrics
Details
- Title
- Associations between neighborhood greenspace and brain imaging measures in non-demented older adults: the Cardiovascular Health Study
- Creators
- Lilah M. Besser - Florida Atlantic UniversityGina S. Lovasi - Drexel UniversityYvonne L. Michael - Drexel UniversityParveen Garg - University of Southern CaliforniaJana A. Hirsch - Drexel UniversityDavid Siscovick - New York Academy of MedicinePhil Hurvitz - University of WashingtonMary L. Biggs - University of WashingtonJames E. Galvin - University of MiamiTraci M. Bartz - University of WashingtonW. T. Longstreth - University of Washington
- Publication Details
- Social Psychiatry and Psychiatric Epidemiology, v 56(9), pp 1575-1585
- Publisher
- Springer Berlin Heidelberg
- Grant note
- R01DK076608; R01CA178343; R01AG049970; R01DK114196; R01HD091089; R01NR016942 / National Institutes of Health (http://dx.doi.org/10.13039/100000002) K01AG063895; 3R01AG049970-04S1; R01AG040211; R01NS101483; 1R01AG049970 / National Institute on Aging (http://dx.doi.org/10.13039/100000049)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative; Epidemiology and Biostatistics
- Web of Science ID
- WOS:000604146100001
- Scopus ID
- 2-s2.0-85098484766
- Other Identifier
- 991019168856204721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Psychiatry