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Asthma and lung structure on computed tomography: The Multi-Ethnic Study of Atherosclerosis Lung Study
Journal article   Open access   Peer reviewed

Asthma and lung structure on computed tomography: The Multi-Ethnic Study of Atherosclerosis Lung Study

Kathleen M. Donohue, Eric A. Hoffman, Heather Baumhauer, Junfeng Guo, Firas S. Ahmed, Gina S. Lovasi, David R. Jacobs, Paul Enright and R. Graham Barr
Journal of allergy and clinical immunology, v 131(2), pp 361-368.e11
Feb 2013
DOI: https://doi.org/10.1016/j.jaci.2012.11.036
PMID: 23374265
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://europepmc.org/articles/pmc3564253View
Accepted (AM) Open Open Access (License Unspecified)

Abstract

Airway remodeling airway structure asthma emphysema epidemiology
The potential consequences of asthma in childhood and young adulthood on lung structure in older adults have not been studied in a large, population-based cohort. The authors hypothesized that a history of asthma onset in childhood (age 18 years or before) or young adulthood (age 19-45 years) was associated with altered lung structure on computed tomography in later life. The Multi-Ethnic Study of Atherosclerosis Lung Study recruited 3965 participants and assessed asthma history by using standardized questionnaires, guideline-based spirometry, and segmental airway dimensions and percentage of low attenuation area (%LAA) on computed tomographic scans. Asthma with onset in childhood and young adulthood was associated with large decrements in FEV1 among participants with a mean age of 66 years (−365 mL and −343 mL, respectively; P < .001). Asthma with onset in childhood and young adulthood was associated with increased mean airway wall thickness standardized to an internal perimeter of 10 mm (0.1 mm, P < .001 for both), predominantly from narrower segmental airway lumens (−0.39 mm and −0.34 mm, respectively; P < .001). Asthma with onset in childhood and young adulthood also was associated with a greater %LAA (1.69% and 4.30%, respectively; P < .001). Findings were similar among never smokers, except that differential %LAA in childhood-onset asthma were not seen in them. Asthma with onset in childhood or young adulthood was associated with reduced lung function, narrower airways, and among asthmatic patients who smoked, greater %LAA in later life.

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Collaboration types
Domestic collaboration
Web of Science research areas
Allergy
Immunology
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