Asthma and lung structure on computed tomography: The Multi-Ethnic Study of Atherosclerosis Lung Study

Kathleen M. Donohue; Eric A. Hoffman; Heather Baumhauer; Junfeng Guo; Firas S. Ahmed; Gina S. Lovasi; David R. Jacobs; Paul Enright; R. Graham Barr

doi:10.1016/j.jaci.2012.11.036

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Asthma and lung structure on computed tomography: The Multi-Ethnic Study of Atherosclerosis Lung Study

Journal article

Open access

Peer reviewed

Asthma and lung structure on computed tomography: The Multi-Ethnic Study of Atherosclerosis Lung Study

Kathleen M. Donohue, Eric A. Hoffman, Heather Baumhauer, Junfeng Guo, Firas S. Ahmed, Gina S. Lovasi, David R. Jacobs, Paul Enright and R. Graham Barr

Journal of allergy and clinical immunology, v 131(2), pp 361-368.e11

Feb 2013

DOI: https://doi.org/10.1016/j.jaci.2012.11.036

PMID: 23374265

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Abstract

Airway remodeling

airway structure

asthma

emphysema

epidemiology

The potential consequences of asthma in childhood and young adulthood on lung structure in older adults have not been studied in a large, population-based cohort. The authors hypothesized that a history of asthma onset in childhood (age 18 years or before) or young adulthood (age 19-45 years) was associated with altered lung structure on computed tomography in later life. The Multi-Ethnic Study of Atherosclerosis Lung Study recruited 3965 participants and assessed asthma history by using standardized questionnaires, guideline-based spirometry, and segmental airway dimensions and percentage of low attenuation area (%LAA) on computed tomographic scans. Asthma with onset in childhood and young adulthood was associated with large decrements in FEV1 among participants with a mean age of 66 years (−365 mL and −343 mL, respectively; P < .001). Asthma with onset in childhood and young adulthood was associated with increased mean airway wall thickness standardized to an internal perimeter of 10 mm (0.1 mm, P < .001 for both), predominantly from narrower segmental airway lumens (−0.39 mm and −0.34 mm, respectively; P < .001). Asthma with onset in childhood and young adulthood also was associated with a greater %LAA (1.69% and 4.30%, respectively; P < .001). Findings were similar among never smokers, except that differential %LAA in childhood-onset asthma were not seen in them. Asthma with onset in childhood or young adulthood was associated with reduced lung function, narrower airways, and among asthmatic patients who smoked, greater %LAA in later life.

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Details

Title: Asthma and lung structure on computed tomography: The Multi-Ethnic Study of Atherosclerosis Lung Study
Creators: Kathleen M. Donohue - Columbia University
Eric A. Hoffman - University of Iowa
Heather Baumhauer - University of Iowa
Junfeng Guo - University of Iowa
Firas S. Ahmed - Columbia University
Gina S. Lovasi - Columbia University
David R. Jacobs - University of Minnesota
Paul Enright - University of Arizona
R. Graham Barr - Columbia University
Publication Details: Journal of allergy and clinical immunology, v 131(2), pp 361-368.e11
Publisher: Mosby, Inc
Grant note: R01 HL077612, R01 HL075476, RC1 HL100543, and N01-HC95159-169 / National Institutes of Health University of Iowa National Institutes of Health (NIH) Boehringer Ingelheim Alpha One Foundation
Resource Type: Journal article
Language: English
Academic Unit: Urban Health Collaborative
Web of Science ID: WOS:000314661500012
Scopus ID: 2-s2.0-84873368534
Other Identifier: 991020100075304721

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Collaboration types: Domestic collaboration
Web of Science research areas: Allergy; Immunology