Journal article
Autism Spectrum Disorder Risk in Relation to Maternal Mid-Pregnancy Serum Hormone and Protein Markers from Prenatal Screening in California
Journal of autism and developmental disorders, v 46(2), pp 478-488
Feb 2016
PMID: 26370672
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We examined prenatal screening markers and offspring autism spectrum disorder (ASD) using California statewide data on singleton births in 1996 and 2002. Second trimester levels of unconjugated estriol (uE3), human chorionic gonadotropin (hCG), and maternal serum alpha-fetoprotein (MSAFP) were compared between mothers of children with ASD (n = 2586) and of non-cases (n = 600,103). Adjusted odds ratios (AOR) were calculated by logistic regression. Lower uE3 (AOR for < 10th percentile vs. 25th-74th percentiles = 1.21, 95 % CI 1.06-1.37), and higher MSAFP (AOR = 1.21, 95 % CI 1.07-1.37 for > 90th percentile) were significantly associated with ASD. A U-shaped relationship was seen for hCG (AOR = 1.16, 95 % CI 1.02-1.32 for < 10th percentile; AOR = 1.19, 95 % CI 1.05-1.36 for > 90th percentile). Our results further support prenatal hormone involvement in ASD risk.
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Details
- Title
- Autism Spectrum Disorder Risk in Relation to Maternal Mid-Pregnancy Serum Hormone and Protein Markers from Prenatal Screening in California
- Creators
- Gayle C Windham - Environmental Health Investigations BranchKristen Lyall - Drexel UniversityMeredith Anderson - Impact AssessmentMartin Kharrazi - Genetics Disease Screening Program
- Publication Details
- Journal of autism and developmental disorders, v 46(2), pp 478-488
- Publisher
- Springer Nature
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- A.J. Drexel Autism Institute
- Web of Science ID
- WOS:000368685700011
- Scopus ID
- 2-s2.0-84955679065
- Other Identifier
- 991020099178804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Psychology, Developmental