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Journal article
Bioisosteric Replacement as a Tool in Anti-HIV Drug Design
Pharmaceuticals (Basel, Switzerland), v 13(3)
01 Mar 2020
PMID: 32121077
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Bioisosteric replacement is a powerful tool for modulating the drug-like properties, toxicity, and chemical space of experimental therapeutics. In this review, we focus on selected cases where bioisosteric replacement and scaffold hopping have been used in the development of new anti-HIV-1 therapeutics. Moreover, we cover field-based, computational methodologies for bioisosteric replacement, using studies from our group as an example. It is our hope that this review will serve to highlight the utility and potential of bioisosteric replacement in the continuing search for new and improved anti-HIV drugs.
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Details
- Title
- Bioisosteric Replacement as a Tool in Anti-HIV Drug Design
- Creators
- Alexej Dick - Drexel UniversitySimon Cocklin - Drexel University
- Publication Details
- Pharmaceuticals (Basel, Switzerland), v 13(3)
- Publisher
- Mdpi
- Number of pages
- 16
- Grant note
- GM125396 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Web of Science ID
- WOS:000523707400013
- Scopus ID
- 2-s2.0-85081008186
- Other Identifier
- 991019168563104721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Chemistry, Medicinal
- Pharmacology & Pharmacy