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Journal article
CAvant (R) WO-60 as an Effective Immunological Adjuvant for Avian Influenza and Newcastle Disease Vaccine
Frontiers in veterinary science, v 8, pp 730700-730700
03 Dec 2021
PMID: 34926633
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Despite the immunogenicity of vaccines currently used in poultry, several pathogens, including avian influenza virus (AIV) and Newcastle disease virus (NDV), cause enormous economic losses to the global poultry industry. The efficacy of vaccines can be improved by the introduction of effective adjuvants. This study evaluated a novel water-in-oil emulsion adjuvant, CAvant (R) WO-60, which effectively enhanced both the immunogenicity of conserved influenza antigen sM2HA2 and inactivated whole H9N2 antigen (iH9N2). CAvant (R) WO-60 induced both humoral and cell-mediated immunity in mice and provided 100% protection from challenge with 10 LD50 of A/Aquatic bird/Korea/W81/2005 (H5N2) and A/Chicken/Korea/116/2004 (H9N2) AIV. Importantly, immunization of chickens with iH9N2 plus inactivated NDV LaSota (iNDV) bivalent inactivated vaccine emulsified in CAvant (R) WO-60 induced seroprotective levels of antigen-specific antibody responses. Taken together, these results suggested that CAvant (R) WO-60 is a promising adjuvant for poultry vaccines.
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Details
- Title
- CAvant (R) WO-60 as an Effective Immunological Adjuvant for Avian Influenza and Newcastle Disease Vaccine
- Creators
- Eun-Seo Lee - Chungnam National UniversityYoung-Jung Shim - Choong Ang Vaccine Laboratory Co., Ltd., Daejeon, South KoreaW. A. Gayan Chathuranga - Chungnam National UniversityYoung-Hoon Ahn - Choong Ang Vaccine Laboratory Co., Ltd., Daejeon, South KoreaIn-Joong Yoon - Choong Ang Vaccine Laboratory Co., Ltd., Daejeon, South KoreaSung-Sik Yoo - Choong Ang Vaccine Lab Co Ltd, Daejeon, South KoreaJong-Soo Lee - Chungnam National University
- Publication Details
- Frontiers in veterinary science, v 8, pp 730700-730700
- Publisher
- Frontiers Media Sa
- Number of pages
- 13
- Grant note
- 316043-3 / Ministry for Food, Agriculture, Forestry and Fisheries, Republic of Korea
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Arts and Sciences; Chemistry; Drexel University
- Web of Science ID
- WOS:000731491700001
- Scopus ID
- 2-s2.0-85121380746
- Other Identifier
- 991020100205504721
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- Web of Science research areas
- Veterinary Sciences