Journal article
Cannabis use and medication nonadherence in bipolar disorder: A nationwide inpatient sample database analysis
Journal of affective disorders, v 299, pp 174-179
15 Feb 2022
PMID: 34863715
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Cannabis use disorder (CUD) is associated with medication nonadherence among patients with BD.Studies have indicated that patients with BD have a specific predisposition to CUD compared to other psychiatric diagnosis.CUD is independently associated with higher medication nonadherence among patients with BD compared to other substance use disorder.Patients with BD identifying as black had the highest adjusted OR for medication nonadherence among races.Multidisciplinary approach that involves collaborative work between general adult psychiatry and addiction services are needed to improve health outcome of patients with BD and comorbid CUD to reduce medication nonadherence .
Medication nonadherence among bipolar disorder (BD) is often linked with comorbid substance use disorders. This study aims to investigate cannabis use disorder (CUD) association with medication noncompliance in hospitalized BD patients.
: Using data on 266,303 BD hospitalizations between 2010 and 2014 from the US Nationwide Inpatient Sample database, we obtained medication noncompliance rates stratified by demographics and CUD. Logistic regression was used to evaluate factors associated with medication noncompliance.
Overall mean age, the prevalence of CUD, and medication nonadherence were 41.58 (± 0.11) years, 15.0% and 16.1%, respectively. There were 56.6% females in the overall population. There was a significant difference in the characteristics of those in the medication nonadherence vs adherence groups, including age, sex, race, comorbid substance use, income, insurance type, hospital region, and hospital teaching status (p < 0.001). After adjusting for other variables using multivariate analysis, there remained a statistically significant association of medication nonadherence in BD hospitalization and CUD (OR 1.42, 95% CI 1.36–1.48).
Confounding multiple substance use could not be accounted for, and the retrospective nature of the database which includes only inpatients is prone to possible selection and reporting bias.
CUD statistically predicts increased rates of medication nonadherence among patients with BD. Given the possible association of CUD with medication nonadherence among BD patients, collaborative work between general adult psychiatry and addiction services is imperative in improving the management outcome of patients with BD and comorbid CUD.
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Details
- Title
- Cannabis use and medication nonadherence in bipolar disorder: A nationwide inpatient sample database analysis
- Creators
- Adeolu Funso Oladunjoye - Baylor College of MedicineSyed Zane Kaleem - Drexel UniversityAishwarya Suresh - Drexel UniversityVikram Sahni - Drexel UniversityMatthew J. Thoonkuzhy - Drexel UniversityGibson Anugwom - Houston Behavioral Healthcare Hospital, Houston TXOlubunmi Oladunjoye - Reading HospitalDavid Otuada - Reading HospitalJoseph Ikekwere - University of Illinois at ChicagoEduardo D Espiridion - Reading Hospital
- Publication Details
- Journal of affective disorders, v 299, pp 174-179
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychiatry; College of Medicine
- Web of Science ID
- WOS:000737054400023
- Scopus ID
- 2-s2.0-85120748831
- Other Identifier
- 991019168661404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology
- Psychiatry