Journal article
Carbohydrate-based inducers of cellular stress for targeting cancer cells
Bioorganic & medicinal chemistry letters, v 26(5), pp 1452-1456
01 Mar 2016
PMID: 26832785
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Small molecules that block the altered metabolism in cancer or increase the production of reactive oxygen species (ROS) are emerging as potential anti-cancer agents. Considering that various carbohydrates can be used for cellular energetics or protein N-glycosylation of which interruption can lead to cellular stress, we have synthesized and evaluated a library of N-aryl glycosides for induction of ROS and cytotoxicity in H1299 cancer cell line. Two N-aryl glycosides (K8 and H8) were identified that induce about 2-fold induction of ROS and cytotoxicity in H1299 cells. We further showed that the acetylated form of K8 (K8A) activates AMPK, and stabilizes p53 in HEK293 cells, and induce a higher cytotoxicity than 2-deoxy-d-glucose in H1299 cell line.
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Details
- Title
- Carbohydrate-based inducers of cellular stress for targeting cancer cells
- Creators
- Fidelis T Ndombera - Wayne State UniversityGarrett C VanHecke - Wayne State UniversityShima Nagi - Wayne State UniversityYoung-Hoon Ahn - Wayne State University
- Publication Details
- Bioorganic & medicinal chemistry letters, v 26(5), pp 1452-1456
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Arts and Sciences; Chemistry; Drexel University
- Web of Science ID
- WOS:000369941600017
- Scopus ID
- 2-s2.0-84957839530
- Other Identifier
- 991020099629804721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Chemistry, Medicinal
- Chemistry, Organic