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Journal article
Cardiometabolic Pregnancy Complications in Association With Autism-Related Traits as Measured by the Social Responsiveness Scale in ECHO
American journal of epidemiology, v 191(8), pp 1407-1419
23 Jul 2022
PMID: 35362025
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Prior work has examined associations between cardiometabolic pregnancy complications and autism spectrum disorder (ASD) but not how these complications may relate to social communication traits more broadly. We addressed this question within the Environmental Influences on Child Health Outcomes program, with 6,778 participants from 40 cohorts conducted from 1998-2021 with information on ASD-related traits via the Social Responsiveness Scale. Four metabolic pregnancy complications were examined individually, and combined, in association with Social Responsiveness Scale scores, using crude and adjusted linear regression as well as quantile regression analyses. We also examined associations stratified by ASD diagnosis, and potential mediation by preterm birth and low birth weight, and modification by child sex and enriched risk of ASD. Increases in ASD-related traits were associated with obesity (beta = 4.64, 95% confidence interval: 3.27, 6.01) and gestational diabetes (beta = 5.21, 95% confidence interval: 2.41, 8.02), specifically, but not with hypertension or preeclampsia. Results among children without ASD were similar to main analyses, but weaker among ASD cases. There was not strong evidence for mediation or modification. Results suggest that common cardiometabolic pregnancy complications may influence child ASD-related traits, not only above a diagnostic threshold relevant to ASD but also across the population.
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Details
- Title
- Cardiometabolic Pregnancy Complications in Association With Autism-Related Traits as Measured by the Social Responsiveness Scale in ECHO
- Creators
- Kristen Lyall (Corresponding Author) - Drexel UniversityXuejuan Ning - Johns Hopkins UniversityJudy L. Aschner - Hackensack Meridian HealthLyndsay A. Avalos - Kaiser PermanenteDeborah H. Bennett - University of California, DavisDeborah A. Bilder - University of UtahNicole R. Bush - University of California, San FranciscoKecia N. Carroll - Icahn School of Medicine at Mount SinaiSu H. Chu - Brigham and Women's HospitalLisa A. Croen - Kaiser PermanenteDana Dabelea - University of Colorado DenverJulie L. Daniels - University of North Carolina at Chapel HillChristiane Duarte - Columbia UniversityAmy J. Elliott - University of South DakotaM. Daniele Fallin - Johns Hopkins UniversityAssiamira Ferrara - Kaiser PermanenteIrva Hertz-Picciotto - University of California, DavisAlison E. Hipwell - University of PittsburghElizabeth T. Jensen - Wake Forest UniversitySusan L. Johnson - University of Colorado Anschutz Medical CampusRobert M. Joseph - Boston UniversityMargaret Karagas - Dartmouth CollegeRachel S. Kelly - Brigham and Women's HospitalBarry M. Lester - Brown UniversityAmy Margolis - Columbia UniversityCindy T. McEvoy - Oregon Health & Science UniversityDaniel Messinger - University of MiamiJenae M. Neiderhiser - Pennsylvania State UniversityThomas G. O'Connor - Departments of Psychiatry, Psychology, Neuroscience, and Obstetrics and Gynecology, University of Rochester, Rochester, NY1AJ Drexel Autism Institute, Drexel University, Philadelphia PA.Emily Oken - Harvard Pilgrim Health CareSheela Sathyanarayana - Seattle Children's Research InstituteRebecca J. Schmidt - University of California, DavisStephen J. Sheinkopf - Brown UniversityNicole M. Talge - Michigan State UniversityKedir N. Turi - Vanderbilt UniversityRosalind J. Wright - Icahn School of Medicine at Mount SinaiQi Zhao - Department of Preventive Medicine, College of Medicine, University of Tennessee.Craig Newschaffer - Pennsylvania State UniversityHeather E. Volk - Johns Hopkins UniversityChristine Ladd-Acosta - Johns Hopkins University
- Publication Details
- American journal of epidemiology, v 191(8), pp 1407-1419
- Publisher
- Oxford University Press
- Number of pages
- 13
- Grant note
- UH3OD023288; UH3OD023389; UH3OD023342; UH3OD023275; UH3OD023271; U01HL091528; UH3OD023349; UH3OD023286; UH3OD023348; UH3OD023285; UH3OD023272; UH3OD023337 / 'Environmental Influences on Child Health Outcomes (ECHO) program, Office of The Director, National Institutes of Health' U2COD023375; U24OD023382; U24OD023319; UH3OD023320; UH3OD023248; UH3OD023313; UH3OD023328; UH3OD023318; UH3OD023279; UH3OD023289; UH3OD023282; UH3OD023365; UH3OD023244; UH3OD023268; UH3OD023347 / Environmental Influences on Child Health Outcomes (ECHO) program, Office of The Director, National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- A.J. Drexel Autism Institute
- Web of Science ID
- WOS:000806377200001
- Scopus ID
- 2-s2.0-85135597497
- Other Identifier
- 991019231658804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health