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Journal article
Chlorpyrifos Exposure and Urban Residential Environment Characteristics as Determinants of Early Childhood Neurodevelopment
American journal of public health (1971), v 101(1), pp 63-70
01 Jan 2011
PMID: 20299657
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Abstract
Objectives. We evaluated whether neighborhood characteristics correlated with early neurodevelopment and whether these characteristics confounded the previously reported association between exposure to chlorpyrifos (an organophosphate insecticide) and neurodevelopment.
Methods. We obtained prenatal addresses, chlorpyrifos exposure data, and 36-month Psychomotor Development Index (PDI) and Mental Development Index (MDI) scores for a birth cohort in New York City (born 1998-2002). We used data from the 2000 US Census to estimate measures of physical infrastructure, socioeconomic status, crowding, demographic composition, and linguistic isolation for 1-kilometer network areas around each child's prenatal address. Generalized estimating equations were adjusted for demographics, maternal education and IQ, prenatal exposure to tobacco smoke, caretaking environment quality, and building dilapidation.
Results. Of 266 children included as participants, 47% were male, 59% were Dominican, and 41% were African American. For each standard deviation higher in neighborhood percent poverty, the PDI score was 2.6 points lower (95% confidence interval [CI]=-3.7, -1.5), and the MDI score was 1.7 points lower (95% CI=-2.6, -0.8). Neighborhood-level confounding of the chlorpyrifos-neurodevelopment association was not apparent.
Conclusions. Neighborhood context and chlorpyrifos exposure were independently associated with neurodevelopment, thus providing distinct opportunities for health promotion. (Am J Public Health. 2011;101:63-70. doi:10.2105/AJPH. 2009.168419)
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Details
- Title
- Chlorpyrifos Exposure and Urban Residential Environment Characteristics as Determinants of Early Childhood Neurodevelopment
- Creators
- Gina S. Lovasi - Columbia UniversityJames W. Quinn - Columbia UniversityVirginia A. Rauh - Columbia UniversityFrederica P. Perera - Columbia UniversityHoward F. Andrews - Columbia UniversityRobin Garfinkel - Columbia UniversityLori Hoepner - Columbia UniversityRobin Whyatt - Columbia UniversityAndrew Rundle - Columbia University
- Publication Details
- American journal of public health (1971), v 101(1), pp 63-70
- Publisher
- Amer Public Health Assoc Inc
- Number of pages
- 8
- Grant note
- Horace Gladys and Roland Harriman Foundation R01ES012468 / NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) Robert Wood Johnson Foundation; Robert Wood Johnson Foundation (RWJF) RR00645 / Irving General Clinical Research Center; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) John Merck Fund M01RR000645 / NATIONAL CENTER FOR RESEARCH RESOURCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) New York Community Trust R827027; 82860901; RD-832141 / US Environmental Protection Agency; United States Environmental Protection Agency Blanchette Hooker Rockefeller Fund Educational Foundation of America Johnson Family Foundation New York Times Company Foundation Marisla Foundation 5P01ES009600; 5R01ES008977; 5R01ES11158; 5R01ES012468; 5R01ES10165 / National Institute of Environmental Health Sciences; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative
- Web of Science ID
- WOS:000285665000017
- Scopus ID
- 2-s2.0-78650875695
- Other Identifier
- 991020100212804721
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- Web of Science research areas
- Public, Environmental & Occupational Health