Journal article
Cholesterol-multilipid interactions in bilayers
Chemistry and physics of lipids, v 58(1), pp 169-173
1991
PMID: 1934194
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
To extend our knowledge of model membrane systems based upon one lipid component, multi-lamellar bilayers were made of cholesterol with two phospholipids in equimolar ratio, and the enthalpy change
δH of the main phase transition of the temary mixture was measured by differential scanning calorimetry (DSC) as a function of increasing cholesterol concentration
c. The lipids were saturated phosphatidylcholines
CnPC of acyl chain length
n, and as the
n of the two lipids became more different (from C13PC/C14PC) to C14PC/C15PC to C14PC/C18PC to C14PC/C19PC) distinct breaks in the
δH versus
c plots were observed. These mixtures displayed only one broad DSC endotherm. Mixtures of an unsaturated lipid C18:1PC (dioleoyl) with C16PC or with C18PC showed two peaks, with each peak being associated with its parent lipid. However, the
δH versus
c plots for each of these peaks showed an initial independence of cholesterol concentration followed by a dependence on cholesterol concentration. These results indicate that, in lipid mixtures, the type of interaction of cholesterol with each lipid component depends on the concentration of cholesterol present.
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Details
- Title
- Cholesterol-multilipid interactions in bilayers
- Creators
- Leonard Finegold - Drexel UniversityMichael A. Singer - Queen's University
- Publication Details
- Chemistry and physics of lipids, v 58(1), pp 169-173
- Publisher
- Elsevier Ireland Ltd
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]
- Web of Science ID
- WOS:A1991FU46400018
- Scopus ID
- 2-s2.0-0025853665
- Other Identifier
- 991019173990804721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Biophysics