Logo image
Back
Cigarette Smoking Is Associated with Subclinical Parenchymal Lung Disease: The Multi-Ethnic Study of Atherosclerosis (MESA)–Lung Study
Journal article   Open access   Peer reviewed

Cigarette Smoking Is Associated with Subclinical Parenchymal Lung Disease: The Multi-Ethnic Study of Atherosclerosis (MESA)–Lung Study

David J. Lederer, Paul L. Enright, Steven M. Kawut, Eric A. Hoffman, Gary Hunninghake, Edwin J. R. van Beek, John H. M. Austin, Rui Jiang, Gina S. Lovasi and R. Graham Barr
American journal of respiratory and critical care medicine, v 180(5), pp 407-414
19 Jun 2009
DOI: https://doi.org/10.1164/rccm.200812-1966OC
PMID: 19542480
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1164/rccm.200812-1966ocView
Published, Version of Record (VoR)Open Access (License Unspecified),  Open

Abstract

B. Chronic Obstructive Pulmonary Disease cigarette smoking computed tomography interstitial lung disease restrictive lung disease spirometry
Rationale : Cigarette smoking is a risk factor for diffuse parenchymal lung disease. Risk factors for subclinical parenchymal lung disease have not been described. Objectives : To determine if cigarette smoking is associated with subclinical parenchymal lung disease, as measured by spirometric restriction and regions of high attenuation on computed tomography (CT) imaging. Methods : We examined 2,563 adults without airflow obstruction or clinical cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis, a population-based cohort sampled from six communities in the United States. Cumulative and current cigarette smoking were assessed by pack-years and urine cotinine, respectively. Spirometric restriction was defined as a forced vital capacity less than the lower limit of normal. High attenuation areas on the lung fields of cardiac CT scans were defined as regions having an attenuation between −600 and −250 Hounsfield units, reflecting ground-glass and reticular abnormalities. Generalized additive models were used to adjust for age, gender, race/ethnicity, smoking status, anthropometrics, center, and CT scan parameters. Measurements and Main Results : The prevalence of spirometric restriction was 10.0% (95% confidence interval [CI], 8.9–11.2%) and increased relatively by 8% (95% CI, 3–12%) for each 10 cigarette pack-years in multivariate analysis. The median volume of high attenuation areas was 119 cm 3 (interquartile range, 100–143 cm 3 ). The volume of high attenuation areas increased by 1.6 cm 3 (95% CI, 0.9–2.4 cm 3 ) for each 10 cigarette pack-years in multivariate analysis. Conclusions : Smoking may cause subclinical parenchymal lung disease detectable by spirometry and CT imaging, even among a generally healthy cohort.

Metrics

8 Record Views
245 citations in Web of Science
239 citations in Scopus

Details

UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

InCites Highlights

Data related to this publication, from InCites Benchmarking & Analytics tool:

Collaboration types
Domestic collaboration
Web of Science research areas
Critical Care Medicine
Respiratory System
Logo image