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Circulatory Effects of Electrical Stimulation of the Carotid Sinus Nerves in Man
Journal article   Open access   Peer reviewed

Circulatory Effects of Electrical Stimulation of the Carotid Sinus Nerves in Man

STEPHEN E. Epstein, G. DAVID Beiser, ROBERT E. Goldstein, MORRIS Stampfer, ANDREW S. Wechsler, GERALD Glick and EUGENE Braunwald
Circulation (New York, N.Y.), v 40(3), pp 269-276
Sep 1969
DOI: https://doi.org/10.1161/01.CIR.40.3.269
PMID: 5810886
url
https://doi.org/10.1161/01.CIR.40.3.269View
Published, Version of Record (VoR)Maybe Open Access (Publisher Bronze),  Open

Abstract

The effects of carotid sinus nerve (CSN) stimulation were studied at rest and during a mild level of supine bicycle exercise in seven patients in whom CSN stimulators had been implanted for the treatment of angina pectoris. At rest, CSN stimulation produced a fall in mean arterial pressure (MAP) averaging 23% and an 8% decrease in cardiac output (CO). Total peripheral resistance (TPR) fell by 14% and forearm vascular resistance (FVR) by 16%. During exercise, MAP fell 16%, but no significant change occurred in CO. Thus, the fall in MAP could be attributed to a reflexly induced decrease in peripheral vascular resistance. Only small decreases occurred in heart rate. No changes in venous tone, central venous pressure, or the maximum transverse end-diastolic diameter of the heart were produced by stimulation either at rest or during exercise. Thus, at rest, CSN stimulation reduces MAP by reflexly decreasing both vascular resistance and CO; during exercise, the diminution in CO no longer occurs. Finally, the venous system does not appear to participate in reflexes activated by CSN stimulation.

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