Journal article
Clinical implications of LDH isoenzymes in hemolysis and continuous‐flow left ventricular assist device‐induced thrombosis
Artificial organs, v 44(3), pp 231-238
Mar 2020
PMID: 31494952
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Pump‐induced thrombosis continues to be a major complication of continuous‐flow left ventricular assist devices (CF‐LVADs), which increases the risks of thromboembolic stroke, peripheral thromboembolism, reduced pump flow, pump failure, cardiogenic shock, and death. This is confounded by the fact that there is currently no direct measure for a proper diagnosis during pump support. Given the severity of this complication and its required treatment, the ability to accurately differentiate CF‐LVAD pump thrombosis from other complications is vital. Hemolysis measured by elevated lactate dehydrogenase (LDH) enzyme levels, when there is clinical suspicion of pump‐induced thrombosis, is currently accepted as an important metric used by clinicians for diagnosis; however, LDH is a relatively nonspecific finding. LDH exists as five isoenzymes in the body, each with a unique tissue distribution. CF‐LVAD pump thrombosis has been associated with elevated serum LDH‐1 and LDH‐2, as well as decreased LDH‐4 and LDH‐5. Herein, we review the various isoenzymes of LDH and their utility in differentiating hemolysis seen in CF‐LVAD pump thrombosis from other physiologic and pathologic conditions as reported in the literature.
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Details
- Title
- Clinical implications of LDH isoenzymes in hemolysis and continuous‐flow left ventricular assist device‐induced thrombosis
- Creators
- Jonathan S. Gordon - Thomas Jefferson University HospitalChelsey T. Wood - Thomas Jefferson University HospitalJessica G. Y. Luc - University of British ColumbiaRyan A. Watson - Thomas Jefferson University HospitalElizabeth J. Maynes - Thomas Jefferson University HospitalJae Hwan Choi - Thomas Jefferson University HospitalRohinton J. Morris - Thomas Jefferson University HospitalHoward Todd Massey - Thomas Jefferson University HospitalAmy L. Throckmorton - Drexel UniversityVakhtang Tchantchaleishvili - Thomas Jefferson University Hospital
- Publication Details
- Artificial organs, v 44(3), pp 231-238
- Publisher
- Wiley
- Number of pages
- 8
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000489515800001
- Scopus ID
- 2-s2.0-85073919920
- Other Identifier
- 991019168074904721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Engineering, Biomedical
- Transplantation