Journal article
Computational fluid dynamics prediction of blood damage in a centrifugal pump
Artificial organs, v 27(10), pp 938-941
Oct 2003
PMID: 14616540
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
This study explores a quantitative evaluation of blood damage that occurs in a continuous flow left ventricular assist device due to fluid stress. Computational fluid dynamics (CFD) analysis is used to track the shear stress history of 388 particle streaklines. The accumulation of shear and exposure time is integrated along the streaklines to evaluate the levels of blood trauma. This analysis, which includes viscous and turbulent stresses, provides a statistical estimate of possible damage to cells flowing through the pump. In vitro normalized index of hemolysis values for clinically available ventricular assist devices were compared to our damage indices. This allowed for an order of magnitude comparison between our estimations and experimentally measured hemolysis levels, which resulted in a reasonable correlation. This work ultimately demonstrates that CFD is a convenient and effective approach to analyze the Lagranian behavior of blood in a heart assist device.
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Details
- Title
- Computational fluid dynamics prediction of blood damage in a centrifugal pump
- Creators
- Xinwei Song - Mechanical and Aerospace Engineering Department, Virginia Artificial Heart Institute, University of Virginia, Charlottesville, VA 22903, USA. xs8d@virginia.eduAmy L ThrockmortonHouston G WoodJames F AntakiDon B Olsen
- Publication Details
- Artificial organs, v 27(10), pp 938-941
- Publisher
- United States
- Grant note
- R01 HL64378-01 / NHLBI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000185874900015
- Scopus ID
- 2-s2.0-0242333304
- Other Identifier
- 991014877897404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Engineering, Biomedical
- Transplantation