Journal article
Crohn's Disease Mortality and Ambient Air Pollution in New York City
Inflammatory bowel diseases, v 30(10), pp 1732-1739
03 Oct 2024
PMID: 37934758
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
BACKGROUND
The worldwide increase in Crohn's disease (CD) has accelerated alongside rising urbanization and accompanying decline in air quality. Air pollution affects epithelial cell function, modulates immune responses, and changes the gut microbiome composition. In epidemiologic studies, ambient air pollution has a demonstrated relationship with incident CD and hospitalizations. However, no data exist on the association of CD-related death and air pollution.
METHODS
We conducted an ecologic study comparing the number of CD-related deaths of individuals residing in given zip codes, with the level of air pollution from nitric oxide, nitrogen dioxide, sulfur dioxide (SO2), and fine particulate matter. Air pollution was measured by the New York Community Air Survey. We conducted Pearson correlations and a Poisson regression with robust standard errors. Each pollution component was modeled separately.
RESULTS
There was a higher risk of CD-related death in zip codes with higher levels of SO2 (incidence rate ratio [IRR], 1.16; 95% confidence interval [CI], 1.06-1.27). Zip codes with higher percentage of Black or Latinx residents were associated with lower CD-related death rates in the SO2 model (IRR, 0.58; 95% CI, 0.35-0.98; and IRR, 0.13; 95% CI, 0.05-0.30, respectively). There was no significant association of either population density or area-based income with the CD-related death rate.
CONCLUSIONS
In New York City from 1993 to 2010, CD-related death rates were higher among individuals from neighborhoods with higher levels of SO2 but were not associated with levels of nitric oxide, nitrogen dioxide, and fine particulate matter. These findings raise an important and timely public health issue regarding exposure of CD patients to environmental SO2, warranting further exploration.
Metrics
Details
- Title
- Crohn's Disease Mortality and Ambient Air Pollution in New York City
- Creators
- Alexandra Feathers (Corresponding Author) - Lenox Hill HospitalGina S Lovasi - Drexel UniversityZoya Grigoryan - Lenox Hill HospitalKade Beem - Environmental Systems Research InstituteSamit K Datta - Skagit Valley HospitalDavid M Faleck - Memorial Sloan Kettering Cancer CenterThomas Socci - Lenox Hill HospitalRachel Maggi - Lenox Hill HospitalArun Swaminath - Lenox Hill Hospital
- Publication Details
- Inflammatory bowel diseases, v 30(10), pp 1732-1739
- Publisher
- Oxford University Press
- Number of pages
- 8
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative; Dana and David Dornsife School of Public Health; Epidemiology and Biostatistics
- Web of Science ID
- WOS:001097803200001
- Scopus ID
- 2-s2.0-85205604953
- Other Identifier
- 991021811727604721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Gastroenterology & Hepatology