Journal article
DNA methylation signatures of prenatal socioeconomic position associated with 36-month language outcomes
Research in developmental disabilities, v 154, 104846
Nov 2024
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Socioeconomic position (SEP), which reflects one’s position in society and access to resources, is strongly tied to neurodevelopment and is associated with epigenetic changes. AIM: This study examined whether DNA methylation signatures of prenatal SEP, measured in birth samples, are associated with child neurodevelopmental outcomes at 36 months of age. METHODS: Prenatal SEP DNA methylation scores were derived using 97 placenta and 127 cord blood biospecimens in the Early Autism Risk Longitudinal Investigation cohort. Participants completed the Mullen Scales of Early Learning (MSEL) and Vineland Adaptive Behavior Scales (VABS) at 36 months of age. Generalized regression analyses, adjusting for maternal age and race, were performed to test the association between SEP methylation score, for each birth biospecimen type, and MSEL and VABS scores. RESULTS: Significant associations were observed between placenta SEP methylation score and MSEL Expressive Language outcomes (beta = −2.7, p = 0.046, 95 % CI [- 5.43, −0.05]) and Receptive Language outcomes (beta = −2.5, p = 0.037, 95 % CI [-4.82, −0.16]). In cord blood, methylation-SEP scores were significantly associated with Receptive Language outcomes (beta = −2.0, p = 0.037, 95 % CI [-3.85, −0.12]). No significant associations were observed with VABS scores. CONCLUSION: Our results confirm associations between prenatal SEP and early childhood language development using a novel empiric DNA methylation measure of exposure
•Prenatal socioeconomic position (SEP) is a strong predictor of neurodevelopmental outcomes.•SEP is associated with epigenetic changes via DNA methylation, which can be used as an empitic measure of exposure.•DNA methylation signatures in blood and placenta capture prenatal SEP and are associated with early language outcomes.
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Details
- Title
- DNA methylation signatures of prenatal socioeconomic position associated with 36-month language outcomes
- Creators
- Meghna Rajaprakash - Kennedy Krieger InstituteMeredith Palmore - Bloomberg (United States)Kelly M. Bakulski - University of Michigan–Ann ArborEllen Howerton - Bloomberg (United States)Kristen Lyall - Drexel UniversityRebecca J. Schmidt - University of California, DavisCraig Newschaffer - Pennsylvania State UniversityLisa A. Croen - Kaiser PermanenteIrva Hertz-Picciotto - University of California, DavisHeather Volk - Bloomberg (United States)Christine Ladd-Acosta - Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USAM. Daniele Fallin - Emory University
- Publication Details
- Research in developmental disabilities, v 154, 104846
- Publisher
- Elsevier; OXFORD
- Number of pages
- 10
- Grant note
- National Institute on Minority Health and Health Disparities: R01MD015407 NIH: R01ES016443 National Institute of Environmental Health Sciences: R01ES017646, R01 ES025531, R01 ES025574
Drs. Ladd-Acosta's contributions were supported by funding from the National Institute on Minority Health and Health Disparities (R01MD015407 [to C.L.] ) . Funding for the EARLI study was provided by NIH (R01ES016443 [to C.N.] ) and Autism Speaks. The DNA methylation measures were funded by the National Institute of Environmental Health Sciences (R01ES017646 [to D.F.] ; R01 ES025531 [to D.F.] ; and R01 ES025574 [to R.J.S.] ) .
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- A.J. Drexel Autism Institute
- Web of Science ID
- WOS:001329646100001
- Scopus ID
- 2-s2.0-85205311103
- Other Identifier
- 991021906083504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Education, Special
- Rehabilitation