Journal article
Design of Axial Blood Pumps for Patients With Dysfunctional Fontan Physiology: Computational Studies and Performance Testing
Artificial organs, v 39(1)
01 Jan 2015
PMID: 25626578
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Limited treatment options for patients having dysfunctional single ventricle physiology motivate the necessity for alternative therapeutic options. To address this unmet need, we are developing a collapsible axial flow blood pump. This study investigated the impact of geometric simplicity to facilitate percutaneous placement and maintain optimal performance. Three new pump designs were numerically evaluated. A transient simulation explored the impact of respiration on blood flow conditions over the entire respiratory cycle. Prototype testing of the top performing pump design was completed. The top performing Rec design generated the highest pressure rise range of 2-38mmHg for flow rates of 1-4L/min at 4000-7000RPM, exceeding the performance of the other two configurations by more than 26%. The blood damage indices for the new pump designs were determined to be below 0.5% and predicted hemolysis levels remained low at less than 7x10(-5)g/100L. Prototype testing of the Rec design confirmed numerical predictions to within an average of approximately 22%. These findings demonstrate that the pumps are reasonably versatile in operational ability, meet pressure-flow requirements to support Fontan patients, and are expected to have low levels of blood trauma.
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Details
- Title
- Design of Axial Blood Pumps for Patients With Dysfunctional Fontan Physiology: Computational Studies and Performance Testing
- Creators
- Dhyaa H. Kafagy - Virginia Commonwealth UniversityThomas W. Dwyer - Virginia Commonwealth UniversityKelli L. McKenna - Virginia Commonwealth UniversityJean P. Mulles - Virginia Commonwealth UniversitySteven G. Chopski - Virginia Commonwealth UniversityWilliam B. Moskowitz - Children's Hospital of Richmond at VCUAmy L. Throckmorton - Virginia Commonwealth University
- Publication Details
- Artificial organs, v 39(1)
- Publisher
- Wiley
- Number of pages
- 9
- Grant note
- U.S. Department of Education GAANN Interdisciplinary Graduate Engineering Education and Research (I-GEEAR) fellowship
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000349373600008
- Scopus ID
- 2-s2.0-84922566743
- Other Identifier
- 991019168261704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Engineering, Biomedical
- Transplantation