Journal article
Discovering proteasomal deubiquitinating enzyme inhibitors for cancer therapy: lessons from rational design, nature and old drug reposition
Future medicinal chemistry, v 10(17), pp 2087-2108
01 Aug 2018
PMID: 30066579
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The ubiquitin proteasome system has been validated as a target of cancer therapies evident by the US FDA approval of anticancer 20S proteasome inhibitors. Deubiquitinating enzymes (DUBs), an essential component of the ubiquitin proteasome system, regulate cellular processes through the removal of ubiquitin from ubiquitinated-tagged proteins. The deubiquitination process has been linked with cancer and other pathologies. As such, the study of proteasomal DUBs and their inhibitors has garnered interest as a novel strategy to improve current cancer therapies, especially for cancers resistant to 20S proteasome inhibitors. This article reviews proteasomal DUB inhibitors in the context of: discovery through rational design approach, discovery from searching natural products and discovery from repurposing old drugs, and offers a future perspective.
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Details
- Title
- Discovering proteasomal deubiquitinating enzyme inhibitors for cancer therapy: lessons from rational design, nature and old drug reposition
- Creators
- Kush Patel - The Barbara Ann Karmanos Cancer InstituteZainab SO Ahmed - Wayne State UniversityXuemei Huang - The Barbara Ann Karmanos Cancer InstituteQianqian Yang - Guangzhou Medical UniversityElmira Ekinci - The Barbara Ann Karmanos Cancer InstituteChristine M Neslund-Dudas - Henry Ford Health SystemBharati Mitra - Wayne State UniversityFawzy AEM Elnady - Cairo UniversityYoung-Hoon Ahn - Wayne State UniversityHuanjie Yang - Harbin Institute of TechnologyJinbao Liu - Guangzhou Medical UniversityQing Ping Dou - The Barbara Ann Karmanos Cancer Institute
- Publication Details
- Future medicinal chemistry, v 10(17), pp 2087-2108
- Publisher
- Future Science Ltd
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Arts and Sciences; Chemistry; Drexel University
- Web of Science ID
- WOS:000443173800007
- Scopus ID
- 2-s2.0-85052697370
- Other Identifier
- 991020099666704721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Chemistry, Medicinal