Journal article
Distinct roles of spinal commissural interneurons in transmission of contralateral sensory information
bioRxiv : the preprint server for biology
18 Feb 2023
PMID: 36824871
Abstract
Crossed reflexes (CR) are mediated by commissural pathways transmitting sensory information to the contralateral side of the body, but the underlying network is not fully understood. Commissural pathways coordinating the activities of spinal locomotor circuits during locomotion have been characterized in mice, but their relationship to CR is unknown. We show the involvement of two genetically distinct groups of commissural interneurons (CINs) described in mice, V0 and V3 CINs, in the CR pathways. Our data suggest that the exclusively excitatory V3 CINs are directly involved in the excitatory CR, and show that they are essential for the inhibitory CR. In contrast, the V0 CINs, a population that includes excitatory and inhibitory CINs, are not directly involved in excitatory or inhibitory CRs but down-regulate the inhibitory CR. Our data provide insights into the spinal circuitry underlying CR in mice, describing the roles of V0 and V3 CINs in CR.
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Details
- Title
- Distinct roles of spinal commissural interneurons in transmission of contralateral sensory information
- Creators
- Olivier D Laflamme - Dalhousie UniversitySergey N Markin - Drexel University, Neurobiology and AnatomyRachel Banks - Atlantic Mobility Action Project, Brain Repair Centre, Department of Medical Neuroscience, Dalhousie University, Halifax, Nova Scotia, CanadaYing Zhang - Atlantic Mobility Action Project, Brain Repair Centre, Department of Medical Neuroscience, Dalhousie University, Halifax, Nova Scotia, CanadaSimon M Danner - Drexel University, Neurobiology and AnatomyTurgay Akay - Atlantic Mobility Action Project, Brain Repair Centre, Department of Medical Neuroscience, Dalhousie University, Halifax, Nova Scotia, Canada
- Publication Details
- bioRxiv : the preprint server for biology
- Publisher
- United States
- Grant note
- R01 NS115900 / NINDS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy; College of Medicine
- Other Identifier
- 991020151064604721