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Journal article
Distinct roles of spinal commissural interneurons in transmission of contralateral sensory information
Current biology, v 33(16), pp 3452-3464
21 Aug 2023
PMID: 37531957
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Crossed reflexes are mediated by commissural pathways transmitting sensory information to the contralateral side of the body, but the underlying network is not fully understood. Commissural pathways coordinating the activities of spinal locomotor circuits during locomotion have been characterized in mice, but their relationship to crossed reflexes is unknown. We show the involvement of two genetically distinct groups of commissural interneurons (CINs) described in mice, V0 and V3 CINs, in the crossed reflex pathways. Our data suggest that the exclusively excitatory V3 CINs are directly involved in the excitatory crossed reflexes, and show that they are essential for the inhibitory crossed reflexes. In contrast, the V0 CINs, a population that includes excitatory and inhibitory CINs, are not directly involved in excitatory or inhibitory crossed reflexes but down-regulate the inhibitory crossed reflexes. Our data provide insights into the spinal circuitry underlying crossed reflexes in mice, describing the roles of V0 and V3 CINs in crossed reflexes.
Crossed-reflex pathways transmit sensory information from one limb to the neural circuits of the other and are crucial for gait stability. Laflamme et al investigate the underlying spinal circuitry. They show the involvement of genetically defined (V0 and V3) commissural interneurons in crossed reflexes and in their state-dependent modulation.
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Details
- Title
- Distinct roles of spinal commissural interneurons in transmission of contralateral sensory information
- Creators
- Olivier D. Laflamme - Dalhousie UniversitySergey N. Markin - Drexel University, Neurobiology and AnatomyDylan Deska-Gauthier - Dalhousie UniversityRachel Banks - Atlantic Mobility Action Project, Brain Repair Centre, Department of Medical Neuroscience, Dalhousie University, Halifax, Nova Scotia, B3T 0A6, Canada. Department of Neurobiology and Anatomy, College of Medicine, Drexel University, Philadelphia, Pennsylvania, 19129, United States of AmericaYing Zhang - Dalhousie UniversitySimon M. Danner - Drexel University, Neurobiology and AnatomyTurgay Akay - Atlantic Mobility Action Project, Brain Repair Centre, Department of Medical Neuroscience, Dalhousie University, Halifax, Nova Scotia, B3T 0A6, Canada. Department of Neurobiology and Anatomy, College of Medicine, Drexel University, Philadelphia, Pennsylvania, 19129, United States of America
- Publication Details
- Current biology, v 33(16), pp 3452-3464
- Publisher
- Elsevier
- Number of pages
- 13
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:001122957200001
- Scopus ID
- 2-s2.0-85167995119
- Other Identifier
- 991021861168204721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Biology
- Cell Biology