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Journal article
Does Cocaine Use Increase Medication Noncompliance in Bipolar Disorders? A United States Nationwide Inpatient Cross-Sectional Study
Curēus (Palo Alto, CA), v 13(7), pp e16696-e16696
28 Jul 2021
PMID: 34466326
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Introduction
Medication noncompliance among bipolar disorder (BD) is often linked with comorbid substance use disorders. This study aims to investigate cocaine use (CU) association with medication noncompliance in hospitalized BD patients.
Methods
Using data on 266,303 BD hospitalizations between 2010-2014 from the US Nationwide Inpatient Sample database, we obtained medication noncompliance rates stratified by demographics and cocaine use. Logistic regression was used to evaluate factors associated with medication noncompliance.
Results
Overall mean age, the prevalence of CU, and medication noncompliance were 41.58 (+0.11) years, 8.34%, and 16.08%, respectively. More than half of BI) patients with comorbid CU were between 40-64 years (54.4%), while more male patients with BD were in the CU group (53.9%). With univariable logistic regression, CU (odds ratio [OR]: 1.77, 95% CI: 1.66-1.88) increased the odds of medication noncompliance among BD patients, and after adjusting for other variables there was sustained increased odds (adjusted odds ratio [aOR]: 1.40, 95% CI: 1.32-1.50).
Conclusion
This study showed that CU is associated with medication noncompliance among hospitalized BD patients. This highlights the importance of addressing CU among BD patients. Given the possible association of CU with medication noncompliance among BI) patients, collaborative work between general adult psychiatry and addiction services is imperative in improving the management outcome of BD patients with comorbid CU.
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Details
- Title
- Does Cocaine Use Increase Medication Noncompliance in Bipolar Disorders? A United States Nationwide Inpatient Cross-Sectional Study
- Creators
- Gibson O. Anugwom - Psychiatry and Behavioral Sciences, West Oaks Behavioral Hospital, Houston, USA.Adeolu O. Oladunjoye - Boston Children's HospitalTajudeen O. Basiru - Dell Children's Medical Center of Central TexasEgbebalakhamen Osa - Psychiatry, Essen Health Care, New York, USA.David Otuada - Reading HospitalVictoria Olateju - Washington Adventist UniversitySolomon Babalola - The University of Texas Health Science Center at HoustonOlubunmi Oladunjoye - Reading HospitalMaria Ruiza Yee - Drexel UniversityEduardo D. Espiridion - Drexel University
- Publication Details
- Curēus (Palo Alto, CA), v 13(7), pp e16696-e16696
- Publisher
- Cureus Inc
- Number of pages
- 9
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychiatry
- Web of Science ID
- WOS:000687714100004
- Other Identifier
- 991019169518004721
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Psychiatry