Journal article
Durability of epicardial ventricular restoration without ventriculotomy
European journal of cardio-thoracic surgery, v 44(3), pp E189-E192
01 Sep 2013
PMID: 23739293
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We previously presented early results employing a technique designed for beating heart, ventricular volume reduction (surgical ventricular restoration, SVR) without ventriculotomy for patients with antero-septal scar and dilated ischaemic cardiomyopathy. Significant volume reduction and clinical improvement were achieved. We now report durability in the first 11 patients available for assessment at 6 and 12 months after operation.
After the Ethics Committee approval, 31 symptomatic patients with left ventricular (LV) dilatation and antero-septal scars underwent operation. The scarred lateral LV wall was apposed to the septal scar with serial paired anchors placed through epicardial transmural catheters, excluding non-viable portions of the chamber. Patients were followed at 1, 3, 6 and 12 months postoperatively with echocardiograms. Data are presented for the first 11 patients for whom core lab echocardiographic data were available at 12 months of follow-up.
LV end-systolic index (LVESVI), percent decreases from baseline at 6 and 12 months were 36.2 +/- 18.3 (P < 0.001) and 39.6 +/- 14.8 (P < 0.001). LV end-diastolic volume index (LVEDVI) percent decreases from baseline at 6 and 12 months were 28.6 +/- 18.8 (P < 0.001) at 6 months and 32.2 +/- 14.9 (P < 0.005) at 12 months. All comparisons were by one-tailed t-tests using paired data.
These results demonstrate the persistence of volume reduction employing a technique designed to be used on beating hearts without ventriculotomy or cardiopulmonary bypass. The extent of volume reduction was consistent with results of conventional SVR in experienced centres. These early data validate the further development of technical iterations leading to a clinical study employing a closed chest endovascular platform.
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Details
- Title
- Durability of epicardial ventricular restoration without ventriculotomy
- Creators
- Andrew S. Wechsler - Drexel UniversityJerzy Sadowski - Jagiellonian UniversityBoguslaw Kapelak - Jagiellonian Univ, Dept Cardiovasc & Transplant Surg, Krakow, PolandKrzysztof Bartus - Jagiellonian UniversityGinteras Kalinauskas - cVilnius University Heart Surgery Center, Vilnius, LithuaniaKestutis Rucinskas - cVilnius University Heart Surgery Center, Vilnius, LithuaniaRobertas Samalavicius - cVilnius University Heart Surgery Center, Vilnius, LithuaniaLon Annest - dBioventrix, Inc., San Ramon, CA, USA
- Publication Details
- European journal of cardio-thoracic surgery, v 44(3), pp E189-E192
- Publisher
- Oxford Univ Press
- Number of pages
- 4
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]
- Web of Science ID
- WOS:000323350400006
- Scopus ID
- 2-s2.0-84882628732
- Other Identifier
- 991019168426304721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Cardiac & Cardiovascular Systems
- Respiratory System
- Surgery