Journal article
Early feasibility evaluation of thoracoscopically assisted transcatheter ventricular reconstruction in an experimental model of ischaemic heart failure with left anteroapical aneurysm
EuroIntervention, v 10(12), pp 1480-1487
01 Apr 2015
PMID: 25912393
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Aims: To test the feasibility of a thoracoscopically assisted, off-pump, transcatheter ventricular reconstruction (TCVR) approach in an ovine model of left ventricular (LV) anteroapical aneurysm.
Methods and results: Myocardial infarction (MI) was induced by coil occlusion of the middle left anterior descending artery and diagonals. Two months after MI creation, TCVR was performed via a minimal thoracotomy in eight sheep. Under endoscopic and fluoroscopic guidance, trans-interventricular septal puncture was performed from the LV epicardial scar. A guidewire was externalised via a snare placed in the right ventricle from the external jugular vein. An internal anchor was inserted over the wire and positioned on the right ventricular septum and an external anchor was deployed on the LV anterior epicardium. Serial pairs of anchors were placed and plicated together to exclude the scar completely. Immediately after TCVR, echo-cardiography showed LV end-systolic volume decreased from pre-procedure 58.8 +/- 16.6 ml to 25.1 +/- 7.6 ml (p<0.01) and the ejection fraction increased from 32.0 +/- 7.3% to 52.0 +/- 7.5% (p<0.01). LV twist significantly improved (3.83 +/- 2.21 vs. pre-procedure -0.41 +/- 0.94, p=0.01) and the global peak-systolic longitudinal strain increased from -5.64% to -10.77% (p<0.05).
Conclusions: TCVR using minimally invasive access techniques on the off-pump beating heart is feasible and resulted in significant improvement in LV performance.
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Details
- Title
- Early feasibility evaluation of thoracoscopically assisted transcatheter ventricular reconstruction in an experimental model of ischaemic heart failure with left anteroapical aneurysm
- Creators
- Yanping Cheng - Cardiovascular Research FoundationGeng-Hua Yi - Cardiovasc Res Fdn, CRF Skirball Ctr Innovat, Orangeburg, NY 10962 USALon S. Annest - BioVentrix, San Ramon, CA USAKevin Van Bladel - BioVentrix, San Ramon, CA USARyan Brown - John Muir Med Ctr, Walnut Creek, CA USAAndrew Wechsler - Drexel UniversityMasahiko Shibuya - Cardiovasc Res Fdn, CRF Skirball Ctr Innovat, Orangeburg, NY 10962 USAGerard B. Conditt - Cardiovasc Res Fdn, CRF Skirball Ctr Innovat, Orangeburg, NY 10962 USAAthanasios Peppas - Cardiovasc Res Fdn, CRF Skirball Ctr Innovat, Orangeburg, NY 10962 USAGreg L. Kaluza - Cardiovasc Res Fdn, CRF Skirball Ctr Innovat, Orangeburg, NY 10962 USAJuan F. Granada - Cardiovasc Res Fdn, CRF Skirball Ctr Innovat, Orangeburg, NY 10962 USA
- Publication Details
- EuroIntervention, v 10(12), pp 1480-1487
- Publisher
- Europa Edition
- Number of pages
- 8
- Grant note
- BioVentrix (San Ramon, CA, USA)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]
- Web of Science ID
- WOS:000356844000019
- Scopus ID
- 2-s2.0-84928389467
- Other Identifier
- 991019168434604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cardiac & Cardiovascular Systems