Journal article
Early gene changes in myocardial ischemia
The Annals of thoracic surgery, v 58(4), pp 1282-1284
01 Oct 1994
PMID: 7944806
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
After certain periods of myocardial ischemia and reperfusion, cardiac dysfunction exists in the absence of myonecrosis. In a blood-perfused isolated rat heart model, we have demonstrated early gene changes that are associated with global myocardial “stuunning.” Early gene changes included elevations in the expression of messenger RNAs for HSP70,
c-myc and
c-fos. Increased expression of messenger RNAs for protooncogenes is an important observation because of the role of protooncogenes as nuclear transcription factors. From these study findings, it would appear that the stunning state is associated with early gene changes that may signal the induction of a hypertrophic process. Subsequent studies are required to demonstrate the exact events which take place in the course of stunning that directly initiate an alteration in gene expression.
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Details
- Title
- Early gene changes in myocardial ischemia
- Creators
- Andrew S. WechslerJohn C. EntwistleThomas YehMai DingEmma R. Jakoi
- Publication Details
- The Annals of thoracic surgery, v 58(4), pp 1282-1284
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine; [Retired Faculty]
- Web of Science ID
- WOS:A1994PL57200091
- Scopus ID
- 2-s2.0-0028109713
- Other Identifier
- 991020705347804721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Cardiac & Cardiovascular Systems
- Respiratory System
- Surgery