Journal article
Ectopic Expression of a Microbial-Type Rhodopsin Restores Visual Responses in Mice with Photoreceptor Degeneration
Neuron (Cambridge, Mass.), v 50(1), pp 23-33
06 Apr 2006
PMID: 16600853
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The death of photoreceptor cells caused by retinal degenerative diseases often results in a complete loss of retinal responses to light. We explore the feasibility of converting inner retinal neurons to photosensitive cells as a possible strategy for imparting light sensitivity to retinas lacking rods and cones. Using delivery by an adeno-associated viral vector, here, we show that long-term expression of a microbial-type rhodopsin, channelrhodopsin-2 (ChR2), can be achieved in rodent inner retinal neurons in vivo. Furthermore, we demonstrate that expression of ChR2 in surviving inner retinal neurons of a mouse with photoreceptor degeneration can restore the ability of the retina to encode light signals and transmit the light signals to the visual cortex. Thus, expression of microbial-type channelrhodopsins, such as ChR2, in surviving inner retinal neurons is a potential strategy for the restoration of vision after rod and cone degeneration.
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Details
- Title
- Ectopic Expression of a Microbial-Type Rhodopsin Restores Visual Responses in Mice with Photoreceptor Degeneration
- Creators
- Anding Bi - Wayne State UniversityJinjuan Cui - Wayne State UniversityYu-Ping Ma - Wayne State UniversityElena Olshevskaya - Drexel University Elkins Park CampusMingliang Pu - Peking UniversityAlexander M. Dizhoor - Drexel University Elkins Park CampusZhuo-Hua Pan - Wayne State University
- Publication Details
- Neuron (Cambridge, Mass.), v 50(1), pp 23-33
- Publisher
- Elsevier Inc
- Number of pages
- 11
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy; Pennsylvania College of Optometry (PCO)
- Web of Science ID
- WOS:000236811300008
- Scopus ID
- 2-s2.0-33645974269
- Other Identifier
- 991022035260104721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences