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Effect of triiodothyronine on postischemic myocardial function in the isolated heart
Journal article   Peer reviewed

Effect of triiodothyronine on postischemic myocardial function in the isolated heart

Margit Kadletz, Patrick G. Mullen, Mai Ding, Luke G. Wolfe and Andrew S. Wechsler
The Annals of thoracic surgery, v 57(3), pp 657-662
01 Mar 1994
DOI: https://doi.org/10.1016/0003-4975(94)90563-0
PMID: 8147637
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

Thyroid dysfunction has been shown to have a significant impact on hemodynamic status and cardiac function. The purpose of this study was to determine the influence of triiodothyronine (T 3) on cardiac functional recovery after ischemia in a dose-dependent manner. Postischemic functional recovery was assessed in isolated rabbit hearts mounted in a modified Langendorff preparation. Left ventricular systolic, diastolic, and peak developed pressures were measured before and after ischemia, and calculated as a percentage of preischemic function. Two cohorts of hearts were studied: the first was exposed to warm ischemia until a myocardial contracture of 4 mm Hg was produced; the second cohort was exposed to warm ischemia until a contracture of 15 mm Hg was observed. In each cohort, T 3 was added to the perfusion solution after ischemia in a physiologic concentration (2.5 × 10 −9 g/mL; 1 × T 3), as well as ten times (2.5 × 10 −8 g/ml; 10 × T 3 and a hundred times (2.5 × 10 −7 g/mL; 100 × T 3) the physiologic concentration. One group, given the carrier only but without T 3, served as the control. Rabbit hearts exposed to a short period of ischemia (4-mm Hg diastolic contracture) showed increased recovery with 1 × T 3 and 10 × T 3,100 x T 3 did not bring about improved left ventricular recovery versus that in the control group. Rabbit hearts in the 15 mm Hg-diastolic contracture cohort showed increased recovery with 10 × T 3 but not with 1 × T 3. 100 × T 3 led to decreased recovery in this cohort versus that in the control group. T 3 supplementation had no influence either on the wet-dry weight ratio of myocardium, measured at the end of reperfusion, or on coronary flow throughout the postischemic period. These findings indicate that T 3 enhances recovery after ischemia in a relatively dose-dependent fashion over a wide therapeutic range.

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Web of Science research areas
Cardiac & Cardiovascular Systems
Respiratory System
Surgery
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