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Effects of Delay in Administration of Potassium Cardioplegia to the Isolated Rat Heart
Journal article   Open access   Peer reviewed

Effects of Delay in Administration of Potassium Cardioplegia to the Isolated Rat Heart

Bruce M. Freedman, Michael K. Pasque, Gary L. Pellom, David W. Deaton, John R. Frame and Andrew S. Wechsler
The Annals of thoracic surgery, v 37(4)
Apr 1984
DOI: https://doi.org/10.1016/S0003-4975(10)60736-9
PMID: 6712332
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1016/S0003-4975(10)60736-9View
Published, Version of Record (VoR)Maybe Open Access (Publisher Bronze),  Open

Abstract

Ischemic injury to the heart in the period between aortic cross-clamping and administration of cardioplegic solution was evaluated in the normothermic rat heart model. After isolation and control perfusion with oxygenated Krebs-Henseleit bicarbonate buffer, the hearts were given lactated Ringer's cardioplegic solution (30 mEq of K + per liter) for 2 minutes at three different intervals following aortic clamping: no delay, 2-minute delay, and 5-minute delay. Thereafter, the hearts were left unper-fused and the time to initiation of ischemic contracture was recorded. Adenosine triphosphate (ATP) and creatine phosphate levels were measured in all groups prior to and at the conclusion of cardioplegia administration. A 2-minute delay in the administration of cardioplegic solution resulted in significantly lower ( p < 0.001) ATP levels that were restored after 2 minutes of cardioplegia administration. Contracture times were not significantly altered. A 5-minute delay resulted in significantly shorter ( p < 0.001) contracture times and significantly lower ( p < 0.001) ATP levels that were not restored to preischemic levels by 2 minutes of cardioplegia administration. The fate of the myocardium may be insensitive to events that occur during the earliest moments of ischemia provided that rapid administration of oxygenated potassium cardioplegia follows the ischemic period and restores preischemic high-energy phosphate stores. However, there is a critical ischemic time during the initial interval before cardioplegia that is associated with an impaired ability of the myocardium to tolerate subsequent ischemia.

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Collaboration types
Domestic collaboration
Web of Science research areas
Cardiac & Cardiovascular Systems
Respiratory System
Surgery
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