Journal article
Effects of triiodothyronine supplementation after myocardial ischemia
The Annals of thoracic surgery, v 56(2), pp 215-222
01 Aug 1993
PMID: 8347001
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Cardiopulmonary bypass causes a “euthyroid-sick” state characterized by low levels of circulating triiodothyronine. Triiodothyronine supplementation in this setting has been postulated to improve postischemic left ventricular function by increasing the availability of myocardial high-energy phosphates. These postulates have not been substantiated, however, using load-independent parameters of left ventricular function and analysis of high-energy phosphate metabolism. To test these hypotheses, 14 healthy pigs (30 to 40 kg) were placed on cardiopulmonary bypass and instrumented with left ventricular minor-axis ultrasonic crystals and micromanometertipped pressure catheters. Hearts were subjected to 30 minutes of global, normothermic ischemia. Triiodothyronine (0.1 mg/kg; n = 7) or placebo (n = 7) was administered in a random, investigator-blinded fashion at the removal of the aortic cross-clamp and after 60 minutes of reperfusion. Hemodynamic, metabolic, and ultrastructural data were obtained before ischemia and after 30, 60, 90, and 120 minutes of reperfusion. By 90 minutes of reperfusion left ventricular contractility had returned to preischemic levels in hearts supplemented with triiodothyronine, despite postischemic myocardial adenosine triphosphate levels of 50% to 60% of baseline in both groups. Ultrastructurally, the sarcoplasmic reticulum and mitochondria were significantly better preserved in the group treated with triiodothyronine. This study suggests that triiodothyronine supplementation significantly enhances postischemic left ventricular functional recovery and that this recovery is due to mechanisms other than enhanced availability of myocardial high-energy phosphates.
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Details
- Title
- Effects of triiodothyronine supplementation after myocardial ischemia
- Creators
- Cornelius M. Dyke - Virginia Commonwealth University Medical CenterMai Ding - Virginia Commonwealth University Medical CenterAnwar S. Abd-Elfattah - Virginia Commonwealth University Medical CenterKathy LoesserRebecca J. Dignan - Virginia Commonwealth University Medical CenterAndrew S. Wechsler - Virginia Commonwealth University Medical CenterDavid R. Salter - Virginia Commonwealth University Medical Center
- Publication Details
- The Annals of thoracic surgery, v 56(2), pp 215-222
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine; [Retired Faculty]
- Web of Science ID
- WOS:A1993LR78100005
- Scopus ID
- 2-s2.0-0027291787
- Other Identifier
- 991020705319104721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Cardiac & Cardiovascular Systems
- Respiratory System
- Surgery