Journal article
Embryonic spinal cord transplants enhance locomotor performance in spinalized newborn rats
Advances in neurology, v 72, pp 291-303
1997
PMID: 8993706
Abstract
The results of the present experiments demonstrate that fetal spinal cord transplants placed into the site of a complete transection in newborn rats permit the development of complex patterns of locomotion. These patterns differ in some respects from normal, but include weight support, appropriate postural adjustment, and coordination between forelimbs and hindlimbs. 5-HT agonists administered to transplanted rats can further modify these motor patterns in ways that may prove able to enhance locomotion. When placed into lesion cavities in adult spinal cord, cells genetically modified to express neurotrophins can survive, differentiate, and mimic at least one consequence of fetal transplants, rescue of axotomized neurons from retrograde cell death.
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Details
- Title
- Embryonic spinal cord transplants enhance locomotor performance in spinalized newborn rats
- Creators
- A Tessler - Drexel University, Medical College of Pennsylvania and Hahnemann University (1993-1996, 1998-2002)I Fischer - Drexel University, Medical College of Pennsylvania and Hahnemann University (1993-1996, 1998-2002)S Giszter - Drexel University, Medical College of Pennsylvania and Hahnemann University (1993-1996, 1998-2002)B T Himes - Drexel University, Medical College of Pennsylvania and Hahnemann University (1993-1996, 1998-2002)D MiyaF MoriM Murray - Drexel University, Medical College of Pennsylvania and Hahnemann University (1993-1996, 1998-2002)
- Publication Details
- Advances in neurology, v 72, pp 291-303
- Number of pages
- 13
- Grant note
- NS 24707 / NINDS NIH HHS P50 NS024707 / NINDS NIH HHS P50 NS024707-149003 / NINDS NIH HHS P50 NS024707-139003 / NINDS NIH HHS NS 10090 / NINDS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Scopus ID
- 2-s2.0-0030635613
- Other Identifier
- 991014877654604721