Journal article
Embryonic versus adult myocardium: Adenine nucleotide degradation during ischemia
The Annals of thoracic surgery, v 48(1)
01 Jul 1989
PMID: 2764588
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Neonatal myocardium demonstrates better recovery from ischemia than does adult tissue. We tested the hypothesis that developmental differences in adenine nucleotide degradation might facilitate recovery by quantitating depletion of high-energy phosphates in nine-day-old embryonic (n = 9) and 15-month-old adult (n = 14) chicken hearts at 15-, 30-, 45-, and 60-minute intervals of normothermic ischemia in vitro. Nucleotides adenosine triphosphate, adenosine diphosphate, and adenosine monopnosphate and nucleosides adenosine, inosine, hypoxanthine, and xanthine were determined by highperformance liquid chromatography. Several observations in metabolite degradative response to ischemia were noted. The embryonic myocardium maintained higher adenosine triphosphate and adenosine monophosphate levels over the course of the investigation than did mature myocardium. Moreover, the adult group showed an increase in diffusible nucleoside pool metabolites. Relative immaturity of enzymes responsible for nucleotide degradation may facilitate postiachemic recovery by preserving nondiffusible high-energy phosphate precursors to participate in salvage resynthesis of adenosine triphosphate.
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Details
- Title
- Embryonic versus adult myocardium: Adenine nucleotide degradation during ischemia
- Creators
- William Kenneth Mask - Duke UniversityAnwar S. Abd-elfattah - Duke UniversityMichael Jessen - Duke Medical CenterLouis A. Brunsting - Duke UniversityJon Lekven - Duke UniversityAndrew S. Wechsler - Duke University
- Publication Details
- The Annals of thoracic surgery, v 48(1)
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine; [Retired Faculty]
- Web of Science ID
- WOS:A1989AL33100023
- Scopus ID
- 2-s2.0-0024346593
- Other Identifier
- 991020705443304721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Cardiac & Cardiovascular Systems
- Respiratory System
- Surgery