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Journal article
Examining the properties and therapeutic potential of glial restricted precursors in spinal cord injury
Neural regeneration research, v 11(4), pp 529-533
01 Apr 2016
PMID: 27212899
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
In the aftermath of spinal cord injury, glial restricted precursors (GRPs) and immature astrocytes offer the potential to modulate the inflammatory environment of the injured spinal cord and promote host axon regeneration. Nevertheless clinical application of cellular therapy for the repair of spinal cord injury requires strict quality-assured protocols for large-scale production and preservation that necessitates long-term
in vitro
expansion. Importantly, such processes have the potential to alter the phenotypic and functional properties and thus therapeutic potential of these cells. Furthermore, clinical use of cellular therapies may be limited by the inflammatory microenvironment of the injured spinal cord, altering the phenotypic and functional properties of grafted cells. This report simulates the process of large-scale GRP production and demonstrates the permissive properties of GRP following long-term
in vitro
culture. Furthermore, we defined the phenotypic and functional properties of GRP in the presence of inflammatory factors, and call attention to the importance of the microenvironment of grafted cells, underscoring the importance of modulating the environment of the injured spinal cord.
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Details
- Title
- Examining the properties and therapeutic potential of glial restricted precursors in spinal cord injury
- Creators
- Kazuo Hayakawa - Nagoya City UniversityChristopher Haas - Drexel UniversityItzhak Fischer - Drexel University
- Publication Details
- Neural regeneration research, v 11(4), pp 529-533
- Publisher
- Medknow Publications & Media Pvt Ltd
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy; Civil, Architectural, and Environmental Engineering
- Web of Science ID
- WOS:000377572700002
- Scopus ID
- 2-s2.0-84976308141
- Other Identifier
- 991019168154004721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Cell Biology
- Neurosciences