Journal article
Experimental Measurements of Energy Augmentation for Mechanical Circulatory Assistance in a Patient-Specific Fontan Model
Artificial organs, v 38(9), pp 791-799
01 Sep 2014
PMID: 24404904
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
A mechanical blood pump specifically designed to increase pressure in the great veins would improve hemodynamic stability in adolescent and adult Fontan patients having dysfunctional cavopulmonary circulation. This study investigates the impact of axial-flow blood pumps on pressure, flow rate, and energy augmentation in the total cavopulmonary circulation (TCPC) using a patient-specific Fontan model. The experiments were conducted for three mechanical support configurations, which included an axial-flow impeller alone in the inferior vena cava (IVC) and an impeller with one of two different protective stent designs. All of the pump configurations led to an increase in pressure generation and flow in the Fontan circuit. The increase in IVC flow was found to augment pulmonary arterial flow, having only a small impact on the pressure and flow in the superior vena cava (SVC). Retrograde flow was neither observed nor measured from the TCPC junction into the SVC. All of the pump configurations enhanced the rate of power gain of the cavopulmonary circulation by adding energy and rotational force to the fluid flow. We measured an enhancement of forward flow into the TCPC junction, reduction in IVC pressure, and only minimally increased pulmonary arterial pressure under conditions of pump support.
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Details
- Title
- Experimental Measurements of Energy Augmentation for Mechanical Circulatory Assistance in a Patient-Specific Fontan Model
- Creators
- Steven G. Chopski - Virginia Commonwealth UniversityOwen M. Rangus - Virginia Commonwealth UniversityWilliam B. Moskowitz - Children's Hospital of Richmond at VCUAmy L. Throckmorton - Virginia Commonwealth University
- Publication Details
- Artificial organs, v 38(9), pp 791-799
- Publisher
- Wiley
- Number of pages
- 9
- Grant note
- U.S. Department of Education GAANN Inter\disciplinary Graduate Engineering Education and Research (I-GEEAR) fellowship award
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000342631600010
- Scopus ID
- 2-s2.0-84925301497
- Other Identifier
- 991019169699804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Engineering, Biomedical
- Transplantation