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Journal article
Externally applied compression therapy for Fontan patients
Translational pediatrics, v 7(1), pp 14-22
01 Jan 2018
PMID: 29441279
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background: Limited therapeutic options are available for Fontan patients with dysfunctional or failing single ventricle physiology. This study describes the evaluation of an alternative, non-invasive, at-home therapeutic compression treatment for Fontan patients. Our hypothesis is that routinely administered, externally applied compression treatments to the lower extremities will augment systemic venous return, improve ventricular preload, and thus enhance cardiac output in Fontan patients.
Methods: To initially evaluate this hypothesis, we employed the NormaTec pneumatic compression device (PCD) in a pilot clinical study (n=2). This device is composed of inflatable trouser compartments that facilitate circumferentially and uniformly applied pressure to a patient's lower extremities. Following an initial health screening, test subjects were pre-evaluated with a modified-Bruce treadmill exercise stress test, and baseline data on cardiorespiratory health was collected. After training, test subjects conducted 6 days of external compression therapy at-home. Subjects were then re-evaluated with a final treadmill stress test and data acquisition of new cardiorespiratory parameters.
Results: Both subjects demonstrated improvement in exercise duration time, peak oxygen volume, and ventilator threshold, as compared to the baseline evaluation.
Conclusions: These findings are promising and provide the foundation for future studies that will focus on increasing study participation (sample size) to better assess the clinical benefit of compression therapy for Fontan patients.
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Details
- Title
- Externally applied compression therapy for Fontan patients
- Creators
- Joseph Hernandez - Virginia Commonwealth UniversitySteven G. Chopski - Drexel UniversitySam Lee - Children's Hospital of Richmond at VCUWilliam B. Moskowitz - Children's Hospital of Richmond at VCUAmy L. Throckmorton - Drexel University
- Publication Details
- Translational pediatrics, v 7(1), pp 14-22
- Publisher
- Ame Publ Co
- Number of pages
- 9
- Grant note
- Frederick Banting Foundation in Richmond, Virginia
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000422657200005
- Scopus ID
- 2-s2.0-85042373685
- Other Identifier
- 991019169694304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Pediatrics